Ovulation Triggering 2 vs 3 Follicles

Infertility Clinical Trial

Official title:

Ovulation Trigger With Less Than 3 Follicles in Stimulated In-vitro Fertilization (IVF) Cycles

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06290921
• Other study ID #: 3472
• Status: Active, not recruiting
• Start date: February 22, 2024
• Est. completion date: February 20, 2025

Study information

• Verified date: February 2024
• Source: Clinique Ovo
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt at least one IVF cycle. Traditionally, IVF cycles producing less than 3 to 4 mature follicles (measuring at least 14 mm) have either been cancelled or converted to intra-uterine insemination (IUI) due to the low pregnancy rates associated with these cycles. The minimal number of follicles required to proceed with egg collection is based on clinical experience, having been determined by weighing the probability of implantation and pregnancy versus the risk of not obtaining quality oocytes or reaching embryo transfer when fewer mature follicles are present. This retrospective quality control study aims to compare pregnancy rates in IVF cycles producing 3 follicles measuring 14 mm and more on trigger day, versus 2 or fewer follicles.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 400
• Est. completion date: February 20, 2025
• Est. primary completion date: December 31, 2024
• Gender: Female
• Age group: 18 Years to 42 Years

Eligibility

Inclusion Criteria:

• Stimulated IVF cycle at clinique ovo
• Patients with a maximum of 3 mature follicles (=14mm) on the day of ovulation trigger

Exclusion Criteria:

• Cycle cancelation due to no follicles
• History of recurrent implantation failure
• Contraindication of ovulation induction medication

Related Conditions & MeSH terms

• Infertility

Intervention

Other:
• Ovulation triggering
Ovulation triggering when women only 2 dominant follicles as opposed to the clinic's standard of 3 follicles or more

Locations

Country	Name	City	State
Canada	Clinique Ovo	Montréal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Clinique Ovo

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Clinical Pregnancy Rate	clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound	6 to 8 weeks after Frozen Embryo Transfer