Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway

Infertility Unexplained Clinical Trial

Official title:

Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway in Spermatozoa and Seminal Plasma of Iraqi Asthenospermic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03361618
• Other study ID #: Babil-5
• Status: Completed
• Phase: N/A
• First received: November 7, 2017
• Last updated: December 4, 2017
• Start date: July 1, 2011
• Est. completion date: June 1, 2012

Study information

• Verified date: December 2017
• Source: Babylon University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.

Description:

The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: June 1, 2012
• Est. primary completion date: June 1, 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 26 Years to 36 Years

Eligibility

Inclusion Criteria:

• The presence of asthenozoospermia in the semen sample.

• Must be unable to reproduce.

Exclusion Criteria:

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Related Conditions & MeSH terms

• Infertility
• Infertility Unexplained

Intervention

Dietary Supplement:
• Zinc Sulfate
The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Locations

Country	Name	City	State
Iraq	Mahmoud Hussein Hadwan	Hilla	Babylon

Sponsors (2)

Lead Sponsor	Collaborator
Babylon University	Ministry of Health, Iraq

Country where clinical trial is conducted

Iraq, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer.	Clinical parameter	up to three months.
Secondary	Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer.	Enzyme	up to three months.
Secondary	Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer.	Enzyme	up to three months.
Secondary	Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer.	Enzyme	up to three months.