Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03361618
Other study ID # Babil-5
Secondary ID
Status Completed
Phase N/A
First received November 7, 2017
Last updated December 4, 2017
Start date July 1, 2011
Est. completion date June 1, 2012

Study information

Verified date December 2017
Source Babylon University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.


Description:

The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.


Recruitment information / eligibility

Status Completed
Enrollment 120
Est. completion date June 1, 2012
Est. primary completion date June 1, 2012
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 26 Years to 36 Years
Eligibility Inclusion Criteria:

- The presence of asthenozoospermia in the semen sample.

- Must be unable to reproduce.

Exclusion Criteria:

- the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Zinc Sulfate
The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Locations

Country Name City State
Iraq Mahmoud Hussein Hadwan Hilla Babylon

Sponsors (2)

Lead Sponsor Collaborator
Babylon University Ministry of Health, Iraq

Country where clinical trial is conducted

Iraq, 

Outcome

Type Measure Description Time frame Safety issue
Primary Measurement the uric acid level in spermatozoa and seminal plasma by using spectrophotometer. Clinical parameter up to three months.
Secondary Measurement the adenosine deaminase activity in spermatozoa and seminal plasma by using spectrophotometer. Enzyme up to three months.
Secondary Measurement the xanthine oxidase activity in spermatozoa and seminal plasma by using spectrophotometer. Enzyme up to three months.
Secondary Measurement the 5'-nucleotidase activity in spermatozoa and seminal plasmaby using the spectrophotometer. Enzyme up to three months.
See also
  Status Clinical Trial Phase
Recruiting NCT05506722 - Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity N/A
Active, not recruiting NCT05896657 - Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713 N/A
Completed NCT06290518 - Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713 N/A
Completed NCT03319654 - Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle N/A
Completed NCT04446572 - Application of Lactobacillus Salivarius CECT5713 in Infertility of Unknown Origin Phase 2
Completed NCT04141436 - Hypnofertility for Women Undergoing In Vitro Fertilization (HWUIVF) N/A
Completed NCT05680350 - Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility N/A
Recruiting NCT04144244 - Comparison of the Effect of Microchip and Density Gradient Methods in Intrauterine Insemination Cycles N/A
Recruiting NCT05599724 - PMA-FERTITHEQUE Biocollection
Completed NCT05190250 - Pro-inflammatory Cytokines and Implantation Process in Women With Primary Idiopathic Infertility
Recruiting NCT05824819 - Endometriosis and Peritoneal Dysbiosis N/A
Recruiting NCT06174298 - The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes Phase 4
Completed NCT03085433 - Sperm Selection by Microfluidic Separation Improves Embryo Quality N/A
Recruiting NCT06342856 - Evaluation of Treatment With Coenzyme Q10 and L-Carnitine on Semen Parameters in Infertile Men With Idiopathic Oligoasthenoteratospermia Early Phase 1
Terminated NCT05390606 - Effects of Flourish HEC and BioGenesis to Improve Conception Phase 1
Completed NCT03178695 - Inovium Ovarian Rejuvenation Trials Phase 1
Not yet recruiting NCT04945265 - Effects of Age and Infertility on Ovarian Granulosa Cell Function
Active, not recruiting NCT03799107 - Developmental Epidemiological Study of Children Born Through Reproductive Technology
Completed NCT05789407 - Organic Pollutants in Pelvic Endometriosis N/A
Withdrawn NCT04184323 - SIRT-1 Antagonism for Endometrial Receptivity Phase 2