Infertility, Male Clinical Trial
— KLINEFELTEROfficial title:
Unraveling the Klinefelter's Disease Physiopathology by Organoid Model
Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men. The investigators will isolate and expand spermatogonial cells from KS patients, then using an organoid model investigators will compare the behavior of these Spermatogonia from KS patients when interacting with four combinations of somatic cell types incorporated in the Extra Cellular Matrix hydrogel.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | April 1, 2025 |
Est. primary completion date | April 1, 2025 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 5 Years to 50 Years |
Eligibility | Inclusion Criteria: - Klinefelter Exclusion Criteria: - Mosaicism |
Country | Name | City | State |
---|---|---|---|
Belgium | Cliniques Universitaires St Luc | Brussels |
Lead Sponsor | Collaborator |
---|---|
Cliniques universitaires Saint-Luc- Université Catholique de Louvain |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Klinefelter's infertility physiopathology | Testicular biopsies will be digested using two steps enzymatic protocol. Cell suspensions will be in vitro cultured during 2 months. The following analyses will be performed: cells counts, cells characterisation by immunofluorescence and RTqPCR specific for the cell type, cells karyotypes. | Up to 60 days with intermediate time analyses at the 5th and 10 th passage of cultures. |
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