Impact of Escitalopram on Sperm DNA Fragmentation

Status Recruiting

Clinical Trial Summary

Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or suicidal ideation. Hormone profiles, semen analysis, sperm DNA fragmentation, and sexual function will be measured at baseline, after 6 weeks of therapy, and 4 weeks after discontinuation of therapy (10 weeks into study).

Clinical Trial Description

SSRI medications, specifically escitalopram is a very commonly prescribed medication among men of reproductive age. Significant evidence exists that they may be harmful for paternal fertility potential in both animal and human studies. However, high quality data is lacking, particularly among commonly used SSRI's such as escitalopram. As such, it is important to properly evaluate the potential effect of escitalopram in a randomized placebo controlled fashion. Results will be important in guiding urologists, psychiatrists and family practitioners regarding discussion surrounding SSRI use in their patients interested in fertility. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03527043
Study type	Interventional
Source	Weill Medical College of Cornell University
Contact	Grace Tan
Phone	212-746-3208
Email	grt2008@med.cornell.edu
Status	Recruiting
Phase	Phase 2
Start date	October 1, 2017
Completion date	February 2029

View Details

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