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NCT04856579 Clinical Trial

Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Infertility, Male Clinical Trial

Official title:
Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04856579
Other study ID # RC-5-4-2021
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2019
Est. completion date December 31, 2020

Study information
Verified date April 2021
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

Description:

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Recruitment information / eligibility
Status Completed
Enrollment 30
Est. completion date December 31, 2020
Est. primary completion date December 31, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 39 Years
Eligibility Inclusion Criteria: - Infertile men - Varicocele - Poor sperm parameters Exclusion Criteria: - Men with systemic diseases - Infertile men due to other causes than varicocele

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Varicocelectomy
Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Locations
Country Name City State
Egypt Benha Faculty of Medecine Banha
Egypt Benha Faculty of Medicine Banha

Sponsors (1)
Lead Sponsor Collaborator
Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary The Quality of Semen According to WHO 2010 guidelines regarding semen analysis
Sperm concentration (to be more than 15 million sperm per milliliter).
Sperm motility (not less than 60% progressive motility).
Sperm morphology (not less than 6% normal morphology).		 6 months
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