Infectious Disease Clinical Trial
Official title:
Assessment of the Optimal Dosing of Piperacillin-tazobactam in Intensive Care Unit Patients: Extended Versus Continuous Infusion
Piperacillin-tazobactam is an acylureido-penicillin-beta-lactamase inhibitor combination and
is frequently used in the empirical treatment of hospital-acquired infections because of its
antipseudomonal activity. Similar to other beta-lactam antibiotics, piperacillin-tazobactam
exhibits time-dependent killing and the T > MIC appears to be the best outcome predictor.
Because a majority of infections are treated empirically, it is necessary to achieve a T >
MIC equal to 50% of the dosing interval (50% T > MIC) against the most likely pathogens,
including those with only moderate susceptibility The aim of this study is to compare the
same dose of piperacillin/tazobactam administered by an extended infusion versus a continuous
infusion. A pharmacokinetic study will be performed in patients treated by extended (loading
dose 4 G/30 min followed by 4 X 4 G /3h) and continuous infusion (loading dose 4 G/30 min
followed by 16G /24h).
A population pharmacokinetic analysis with Monte Carlo simulations will be used to determine
95% probability of target attainment (PTA95) versus MIC
n/a
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