Infection Clinical Trial
Official title:
Alteration of the Immune Response in Bacterial Infection
The pilot study "ARIIBO" was conducted to analyze changes in immune parameters reported in
obese subjects, which had never been the subject of a global study outside of an infectious
context, and studied in period septic only sporadically. This study was intended to
contribute to a better understanding of the probably adverse impact of obesity on the immune
response to bacterial infections, and to describe a specific immunological profile of an
infectious excess risk in obese subjects.
In terms of infection, obesity is a risk factor due to "mechanical" and pharmacodynamic
variations, but also to the immune system. One of the best studied immunological parameters
in obese patients, leptin resistance, is associated with a decrease in innate and adaptive
immunity through a modification of the lymphocyte and cytokine profile.
It is important to compare the data collected in obese patients infected (first study called
"ARIIBO"), with those of non-obese subjects presenting the same type of infection, which will
be included in the study "ARIIBACT"
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