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Clinical Trial Summary

Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.


Clinical Trial Description

Primary Objective: Comparable levels of vancomycin will be found in distal femur, proximal tibia, and periarticular soft tissues, as well as in systemic levels, between the intravenous and intraosseous administration groups. Secondary Objective: Compare 30- and 90-day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) versus the interventional group (intraosseous administration of vancomycin). The research team hypothesizes that there will be no difference in complication (infection) rates between groups ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05705843
Study type Interventional
Source The Methodist Hospital Research Institute
Contact Thomas C Sullivan, BS
Phone 346-238-1603
Email tsullivan@houstonmethodist.org
Status Recruiting
Phase Phase 4
Start date January 25, 2023
Completion date January 25, 2024

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