Impaired Glucose Tolerance Clinical Trial
Official title:
Effect of the Administration of Chlorogenic Acid on Glucemic Control, Insulin Secretion and Insulin Sensitivity in Patients With Impaired Glucose Tolerance
Chlorogenic acid has demonstrated promising effects in the treatment of glycemic control, obesity, dyslipidemia, insulin secretion, among others. The above mentioned findings show that Chlorogenic acid has an excellent potential for the control of glucose as well as insulin secretion and insulin sensitivity.
A randomized, double-blind, placebo-controlled clinical trial was carried out in 30 patients
with a diagnosis of impaired glucose tolerance in accordance with the American Diabetes
Association criteria. The patients received 400 mg capsules of Chlorogenic acid or placebo,
three times daily 1/ 2 hour before meals for 90 days. Before and after intervention the
investigators evaluated: 2 hours plasma glucose, glycated hemoglobin (A1C), triglycerides,
high-density lipoprotein, fasting glucose and blood pressure body weight, body mass index,
waist circumference, total cholesterol, low-density lipoprotein, very-low-density
lipoprotein, creatinine, aspartate transaminase and alanine transaminase.
Were calculated: Areas under the curve of glucose and insulin were calculated with de
Trapezoidal formula. Total insulin secretion was evaluated with the Insulinogenic index and
the insulin sensitivity was estimated using the Matsuda index.
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