Toripalimab Plus FLOT in Locally Advanced Gastric Cancer

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

Neoadjuvant therapy for locally advanced gastric cancer is still in the exploratory stage. With the emergence of immune checkpoint inhibitors, neoadjuvant chemoimmunotherapy is also in the exploratory stage in locally advanced gastric cancer. At present, chemotherapy combined with immunotherapy is usually a simple combination of chemotherapeutic drugs and immune drugs, without taking into account of the influenece of applied sequence. The purpose of this study is to explore whether the sequence of chemotherapy and immunotherapy influence the complete pathological response rate in locally advanced gastric cancer. All patients received toripalimab plus FLOT regimen. If pCR was achieved, the patients received two cycles of toripalimab plus FLOT, then toripalimab maintenance until one year, if pCR was not achieved, the patients received 8 cycles of perioperative toripalimab plus FLOT, then toripalimab maintenance until one year. ;

Study Design

Related Conditions & MeSH terms

Chemotherapy
Immune Checkpoint Inhibitor
Locally Advanced Gastric Carcinoma
Stomach Neoplasms

Clinical Trial Details

NCT number	NCT04891016
Study type	Interventional
Source	Henan Cancer Hospital
Contact	Quanli Gao, M.D
Phone	+8637165587483
Email	gaoquanli2015@126.com
Status	Recruiting
Phase	Phase 2
Start date	June 25, 2021
Completion date	May 11, 2025

View Details

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