Gynecologic Cancer Clinical Trial
Official title:
A Perspective Study of Cancer-related Fatigue in Gynecologic Cancer Patients Under Chemotherapy
Chemotherapy is effective and most often used to treat cancer. The common drugs used on
gynecologic cancer treatment include platinum compounds like cisplatin and carboplatin, which
combined with taxane, topotecan, or liposomal doxorubicin to date. The most side effects of
chemotherapy are esophagitis, mucositis, anxiety, nausea, vomiting, abdominal convulsion,
painful swallowing, fatigue and sometimes diarrhea, dizziness, allergy (rash, itching),
neutropenia, thrombocytopenia (fever, chills, cough, pain), anemia and bleeding.
Cancer-related fatigue (CRF), an indicator of quality of life, is a highly prevalent symptom
(75-80%) during treatment and in patients with advanced cancer, yet is sometimes ignored.
Fatigue affected their life more than pain. Proposed criteria for CRF have been adopted for
inclusion in the International Statistical Classification of Disease and Related Health
Problems, Tenth Revision, Clinical Modification (ICD-10-CM). Therefore, more in-depth
researches on CRF are needed in Taiwan. Patients with CRF in need of improvement, commonly
use nutrition supplements, acupuncture, healthy food, massage, drugs, etc. Hence, patients
with CRF could consult their vital physician for an appropriate treatment. Furthermore,
several drugs could be chosen to relieve CRF, including anemia drugs, antipsychotics or
Astragalus polysaccharides extract.
The objective of this retrospective study is to collect and analyze the medical records of
gynecologic cancer patients who who had received chemotherapy with or without prescription
drug treatment for cancer-related fatigue in the Department of Obstetrics & Gynecology of
Tri-Service General Hospital from December 1st, 2015 to Dec 31st, 2018. This study will
compare the fatigue improvement profile by different chemotherapy regimens, tumor stage, CRF
treatment, etc. and investigate the association between the profile of fatigue improvement
and fatigue cluster (weight loss and other symptoms of functional assessment of cancer
therapy). This study will also collect blood specimens and analyze the correlation of the
cytokine profile and/or immune profile.These results will supply physicians with more
understanding about CRF, and help them to enhance the quality on gynecologic cancer care to
being perfected in the future.
About 60 gynecologic cancer patients' medical records are expected to collect and analyze in this retrospective study. The data collection from medical records of gynecologic cancer patients who had received chemotherapy with or without prescription drug treatment for cancer-related fatigue include the demographic information (e.g., height, weight, age, sex, tumor stage, time from tumor diagnoses, prescription drug of cancer-related fatigue treatment and chemotherapy toxicities), the diagnosis and severity of cancer-related fatigue, functional assessment of cancer therapy and so on. ;
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