Hyperventilation in Patients With Traumatic Brain Injury

Status Completed

Clinical Trial Summary

Elevated intracranial pressure is a dangerous and potentially fatal complication after traumatic brain injury. Hyperventilation is a medical intervention to reduce elevated intracranial pressure by inducing cerebral vasoconstriction, which might be associated to cerebral ischemia and hypoxia.

The main hypothesis is that a moderate degree of hyperventilation is sufficient to reduce the intracranial pressure without inducing cerebral ischemia.

Clinical Trial Description

In patients with severe traumatic brain injury (TBI), and with intracranial pressure-monitoring, brain tissue oxygen tension and/or microdialysis probes hyperventilation-tests are performed in the acute phase after trauma. Data are collected and TCCD measurements are performed at baseline, at the beginning of moderate hyperventilation, after prolonged moderate hyperventilation (for 50 minutes) and after return to baseline.

The present study aims to quantify potential adverse effects of moderate short-term hyperventilation during the acute phase of the severe TBI on cerebral hemodynamics, oxygenation, and metabolism. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03822026
Study type	Interventional
Source	University of Zurich
Contact
Status	Completed
Phase	N/A
Start date	May 20, 2014
Completion date	May 2, 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05923840` - Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia	N/A
Completed	`NCT05488301` - Effects of Chest Physiotherapy in Hyperventilation Syndrome
Not yet recruiting	`NCT05222711` - The Use of a Monitoring Device by General Practitioners During Out-of-hours Care	N/A
Recruiting	`NCT05846425` - Investigating the Effect of Yoga-based Breathing Styles on the Human Brain, With a Focus on Memory	N/A
Recruiting	`NCT04974060` - Treatment of Spontaneous Hyperventilation With Remifentanil in Traumatic Brain Injury Patients	N/A
Recruiting	`NCT04940273` - Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage	N/A
Recruiting	`NCT05565430` - Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.
Active, not recruiting	`NCT00895219` - Physiotherapy and Dysfunctional Breathing	Phase 3
Recruiting	`NCT03384849` - Evaluation of an MRI-compatible Vital Signs Sensor System	N/A
Completed	`NCT04232059` - The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery	N/A
Completed	`NCT01575665` - Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study	N/A
Completed	`NCT03614806` - Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis	N/A
Completed	`NCT02743299` - Investigation of a Novel Turbine-driven Ventilator for Use in Cardiopulmonary Resuscitation	Phase 0
Completed	`NCT03240497` - Effects of Cold Exposure and Breathing Techniques on Immune Response	N/A