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Laser Induced Bioengineered Remodeling of Thermally Injured Skin Trial — LIBERTI  

Hypertrophic Scars Clinical Trial

Official title:
Laser Induced Bioengineered Remodeling of Thermally Injured Skin Trial: The Sequential Multiple Assignment Randomized Trial (SMART) Approach to Treatment of Hypertrophic Burn Scars

Clinical Trial Summary

This study will evaluate the efficacy of pulsed dye laser (PDL) and carbon dioxide (CO2) laser in conjunction with usual care (MED) for the treatment of hypertrophic burn scars and will determine the optimal sequence and timing of lasers and usual care.

Clinical Trial Description

The investigator will compare usual care (MED), which will be offered to all patients, to two types of laser treatment (PDL and CO2), which the investigators hypothesize to be beneficial. The timing and sequence of therapy will be randomized, but all patients will receive some form of laser treatment. If the investigators simply stopped at the end of Aim 1, the investigators would complete a traditional randomized control trial (RCT), with some patients potentially receiving laser treatment. However, the investigators are interested in determining whether the sequence of laser treatments is beneficial; therefore, the investigators will be employing a sequential multiple assignment randomized trial (SMART) design. Because of the nature of the study and SMART design, the investigators will offer all patients some form of laser therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02655211
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact
Status Withdrawn
Phase N/A
Start date December 2016
Completion date December 2017
View Details
See also
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Active, not recruiting NCT01113125 - Scars After Central Venous Catheters Phase 3
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Completed NCT00142441 - Effect of Pulse Width on Scar Treatment Using a 595-nm Pulsed Dye Laser N/A
Completed NCT01078428 - Effect of Transparent, Self-drying Silicone Gel on the Treatment of Hypertrophic Abdominal Scars Phase 4
Completed NCT02487212 - Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery Phase 4
Active, not recruiting NCT04532840 - Effect of Cryotherpy on Hypertrophic Scar Phase 2/Phase 3
Recruiting NCT00548210 - Effectivity of Dermatix in Promoting Scar Maturation Phase 3