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Role of ARNi in Ventricular Remodeling in Hypertensive LVH — REVERSE-LVH  

Hypertensive Heart Disease Clinical Trial

Official title:
Role of ARNi in Ventricular Remodeling in Hypertensive LVH

Clinical Trial Summary

In Singapore, hypertension is very common in the adult population. Hypertensive heart disease is a leading cause of heart failure and cardiovascular death. Current management relies primarily on achieving blood pressure targets. However, the optimal blood pressure goals are controversial and there are inherent difficulties in measuring blood pressure using external devices applied to peripheral arteries. As a result of (usually longstanding) hypertension, the heart thickens (i.e. hypertrophies) to maintain function. Ultimately, HF may occur due to long standing energy deficits, muscle injury/death and diffuse interstitial fibrosis (heart muscle scarring). In an ongoing study (REMODEL, ClinicalTrial.gov Identifier NCT02670031), we have been able to undertake preliminary analyses with respect to factors associated with the development of fibrosis. In this randomize controlled trial, we will be examining a novel therapy that has the potential to induce regression cardiac hypertrophy and fibrosis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03553810
Study type Interventional
Source National Heart Centre Singapore
Contact
Status Recruiting
Phase Phase 2
Start date April 12, 2019
Completion date December 31, 2023
View Details
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