SHAPE of Portal Hypertension in Children

Status Recruiting

Clinical Trial Summary

Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threatening complications, the most frequent of which is bleeding from esophageal varices. In children, variceal bleeds are associated with mortality rates of 1-3 %, while life-threatening complications have been reported in up to 20 % of children with cirrhosis. Despite the high incidence of portal hypertension in children with liver disease, a noninvasive modality to monitor disease progression and risk of complications is currently lacking. Hence, this trial will investigate the safety and efficacy of subharmonic aided pressure estimation (SHAPE) as a noninvasive ultrasound technique for diagnosing portal hypertension in children.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04720456
Study type	Interventional
Source	Thomas Jefferson University
Contact	Morgan L Gabbert, MA
Phone	267-426-0820
Email	gabbertm@email.chop.edu
Status	Recruiting
Phase	Phase 2
Start date	November 3, 2021
Completion date	August 2024

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See also
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