Central Arterial Hemodynamics and Resistance Training

Hypertension Clinical Trial

Official title:

Central Blood Pressure and Arterial Hemodynamic Responses to High-intensity Resistance Exercise Training - the Application of Ultrafast Ultrasound Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04546308
• Other study ID #: 201903034RIND
• Status: Completed
• Phase: N/A
• Start date: December 21, 2019
• Est. completion date: July 31, 2022

Study information

• Verified date: February 2022
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Resistance exercise training is one of the popular exercise modes that has been drawn the public's attention. However, existing evidence showed high-intensity resistance exercise training-induced negative adaptation on vascular function and blood pressure responses. Upper-body resistance exercise training is more likely to induced arterial stiffening, which has been shown to be gender-dependent. It is still unknown whether age also plays a role. We like to test the hypothesis that high-intensity upper body resistance exercise may lead to a higher increase of arterial stiffness, central blood pressure, and hemodynamic parameters in younger adults than older adults. We also hypothesize high intensity resistance training could contribute to greater central hemodynamic responses and muscle stiffness than the control; the change of muscle stiffness correlates with the change of hemodynamic parameters. Collectively, study 1 in this project is aimed to recruit 40 apparently healthy young (20-35yrs) and middle-aged to older adults (50-75yrs) into this study followed by upper-body or lower-body high-intensity exercise (80% 1 repetition maximum, 10 reps, 4 sets) by a randomized order. Blood draw, central blood pressure, hemodynamics will be performed and obtained at pre-, immediately-post, 20min, 40mins, and 60 mins post-exercise. Study 2 is aimed to investigate the effects of 8-week whole-body resistance exercise training followed by a 4-week detraining on above-measured variables in order to determine the long-term effects on resistance training. We will employee state-of-art ultrafast ultrasound to obtain muscle stiffness and carotid local pulse wave velocity. Endothelin-1 and catecholamines will also be measured to discover its underlying mechanisms on such stiffening effects induced by high-intensity resistance exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Est. completion date: July 31, 2022
• Est. primary completion date: July 31, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 75 Years

Eligibility

Inclusion Criteria:

• Healthy middle-aged to older adults

Exclusion Criteria:

• (1)BMI?27, (2) Smoking habits for more than six months in the past, (3) Hypertension (blood pressure>140/90 mmHg), (4) Personal diabetes history (fasting blood sugar >126 mg /dL), heart disease, or other cardiovascular diseases, (5) bone damage, (6) regular use of supplements or vitamins

Related Conditions & MeSH terms

• Cardiovascular Risk Factor
• Hypertension

Intervention

Other:
• Resistance exercise training
Eight weeks whole-body resistance exercise training (80%1 repetition maximal, 3 sessions per week) followed by a 4-week detraining intervention

Locations

Country	Name	City	State
Taiwan	National Taiwan University	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Central blood pressure	Carotid blood pressure obtained by using tonometer	Pre, 8th and 12th week
Primary	Muscle shear wave velocity	Shear wave velocity measured by using ultrafast ultrasound	Pre, 8th and 12th week
Primary	Arterial pulse wave velocity	Pulse wave velocity measured by using a commercialized vascular monitor.	Pre, 8th and 12th week
Secondary	Vascular related biomarkers	Catecholamines, endothelin-1	Pre, 8th and 12th week