Hypertension Clinical Trial
Official title:
Evaluation of Soybean Peptides Product on Regulation of Blood Pressure Effect by Clinical Trial
NCT number | NCT03828955 |
Other study ID # | CS15123 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | March 2016 |
Est. completion date | January 2017 |
Verified date | May 2021 |
Source | Chung Shan Medical University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is the report to assess supplementation with soybean peptides on blood pressure among people with mild hypertension. Overall, soybean peptide consumption for 8 weeks could successfully reduce mean diastolic and systolic BP through the suppression of Angiotensin-converting enzyme (ACE) linked to downstream suppression of angiotensin II formation, which further decreases the sympathetic outflow that leads to hypertension.
Status | Completed |
Enrollment | 30 |
Est. completion date | January 2017 |
Est. primary completion date | October 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 80 Years |
Eligibility | Inclusion Criteria: - Eligible subjects were untreated hypertensive men or women aged between 20 and 80 years old with SBP between 120 and 159 mmHg and/or DBP between 80 and 99 mmHg as measured in a sitting position Exclusion Criteria: - Subjects were excluded if they had a history of major cardiovascular disease or severe liver dysfunction; - Diastolic blood pressure = 100 mmHg or Systolic blood pressure = 160 mmHg; - Alcoholic; - US-controlled diabetics; - Stoke in past one year; - Mental diseases or melancholia; - Pregnancy or breast-feeding a child; - Renal dysfunction; - Allergic to Soybean peptides. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chung Shan Medical University | Taichung |
Lead Sponsor | Collaborator |
---|---|
Chung Shan Medical University |
Taiwan,
Lo WM, Li-Chan EC. Angiotensin I converting enzyme inhibitory peptides from in vitro pepsin-pancreatin digestion of soy protein. J Agric Food Chem. 2005 May 4;53(9):3369-76. — View Citation
Rizzello CG, Cassone A, Di Cagno R, Gobbetti M. Synthesis of angiotensin I-converting enzyme (ACE)-inhibitory peptides and gamma-aminobutyric acid (GABA) during sourdough fermentation by selected lactic acid bacteria. J Agric Food Chem. 2008 Aug 27;56(16):6936-43. doi: 10.1021/jf800512u. Epub 2008 Jul 16. — View Citation
Yoshiji H, Kuriyama S, Fukui H. Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor. Tumour Biol. 2002 Nov-Dec;23(6):348-56. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The soy bean peptides anti-hypertensive measure blood pressure (SBP and DBP) | values chang of systolbbic and diastolic BPs between before to after 8 weeks | 8 weeks |
Status | Clinical Trial | Phase | |
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