Hypertension Clinical Trial
Official title:
Effect of Morning Versus Evening Perindopril on Blood Pressure Control in People With Type 2 Diabetes
We assessed the influence of time of administration of ACE inhibitors on circadian blood pressure control in sub Saharan type 2 diabetes patients with stage 1 hypertension over 56 days as first line treatment.
Background: Renin-angiotensin system antagonists represent the mainstay of blood pressure
(BP) lowering treatment options in people with diabetes. ACE inhibitors have a long half-life
and offer the advantage of a single daily dose, usually empirically taken in the morning.
Objective: We assessed the influence of time of administration of ACE inhibitors on circadian
BP control in type 2 diabetes (T2D) patients with stage 1 hypertension.
Methods: Twenty T2D patients (9 being women) with a mean age of 58.7 years, diagnosed with
stage 1 of hypertension and naive to BP lowering medications, were included. They were
randomly allocated to receive perindopril 10 mg/day as a monotherapy either in the morning or
in the evening for 28 days, with crossover without washout period on day 29th and additional
28 days follow-up. A 24-hour ambulatory BP monitoring (ABPM) was performed at baseline, days
28 and 56.
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