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NCT03177408 Clinical Trial

Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients

Hypertension Clinical Trial

Official title:
Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT03177408
Other study ID # 2017032901
Secondary ID
Status Not yet recruiting
Phase N/A
First received April 16, 2017
Last updated June 4, 2017
Start date August 15, 2017
Est. completion date December 31, 2017

Study information
Verified date June 2017
Source Affiliated Hospital of Hebei University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 100
Est. completion date December 31, 2017
Est. primary completion date December 31, 2017
Accepts healthy volunteers No
Gender All
Age group 30 Years to 70 Years
Eligibility Inclusion Criteria:

All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy.

Exclusion Criteria:

Individuals already under treatment for hypertension were not include.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Jing Li

Outcome
Type Measure Description Time frame Safety issue
Primary Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position. on the day of admission
Secondary Differences of HMGB1 levels between grades of diastolic dysfunction Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position. on the day of admission
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