Effect of Vit D on New-onset AF in Hypertension

Hypertension Clinical Trial

Official title:

Relation of Low Vitamin D Levels and New-onset AF Among Hypertensive Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02298738
• Other study ID #: AnkaraU
• Status: Completed
• Phase: N/A
• First received: November 20, 2014
• Last updated: November 21, 2014
• Start date: January 2012
• Est. completion date: November 2014

Study information

• Verified date: November 2014
• Source: Ankara University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Atrial fibrillation (AF), an important cause of cardiac mortality and morbidity is the most common type of cardiac arrhythmia in clinical practice. Hypertensive individuals are at particular risk of development of atrial fibrillation. Renin-angiotensin-aldosteron system (RAS) which is activated in hypertension may be the underlying mechanism of AF among hypertensive patients.

Vitamin D deficiency has been shown to be involved in the pathogenesis of hypertension, cardiovascular disease and obesity. Increased RAS activity is one of the postulated mechanisms by which vitamin D deficiency may trigger the development of hypertension and various cardiovascular diseases. On the basis of these data we hypothesized that hypovitaminosis D might be associated with new-onset AF among patients with hypertension.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 227
• Est. completion date: November 2014
• Est. primary completion date: November 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Hypertensive patients with new-onset AF

Exclusion Criteria:

Established coronary artery disease

• Heart failure

• Chronic obstructive pulmonary disease

• Diabetes mellitus

• Significant heart valve disease

• Hyperthyroidism

• Renal failure

• Any malignancy

• Acute infection

• Recent thoracic or abdominal surgery

• Under therapy of Vit D3

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Atrial Fibrillation
• Hypertension

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ankara University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	hypovitaminosis D	Identifying whether hypovitaminosis D is a risk factor for development of new-onset AF among hypertensive patients	Baseline	No