Hypertension Clinical Trial
Official title:
Central and Peripheral 24-h Blood Pressure Monitoring in Patients With Hypertension and Obstructive Sleep Apnea Before and After Treatment With Continuous Positive Airway Pressure.
The purpose of this study is to examine the effect on blood pressure of 3 months of
treatment with continuous positive airway pressure (CPAP) in patients with obstructive sleep
apnea (OSA).
Hypothesis:
1. Central 24-h blood pressure (BP) monitoring hedges day fluctuations in blood pressure
more accurately than peripheral 24-h BP monitoring, because the measurement is painless
and does not interfere with the patient / subject's activities during the daytime or
nighttime sleep.
2. Blood pressure is elevated in patients with OSA and falls during treatment with CPAP.
3. The renal treatment of salt and water is abnormal in OSA, improved during treatment with
CPAP.
4. Quality of life improves during treatment with CPAP
Approximately 20 patients with hypertension and moderate to severe OSA are treated with CPAP
3 months to examine the treatment effect on blood pressure throughout the day, but
especially nocturnal, renal treatment of salt and water, and quality of life.
Before and after 3 months of CPAP treatment is made central and peripheral 24-h ambulatory
blood pressure monitoring, 24-h urine collection and blood samples.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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