Hypertension Clinical Trial
Official title:
Cardiovascular-Renal Consequences of Reducing Renal Mass After Living Kidney Donation
- A reduce in renal mass may result in remnant single nephron hyperfiltration, with
associated proteinuria and an accelerated loss of kidney function.
- Live-donor kidney transplantation is generally considered the best choice for patients
who have renal failure and are awaiting transplantation, because these kidneys function
better than kidneys from deceased donors, and waiting times for deceased-donor
transplants are long
- Although several studies have shown that kidney donation has low short-term morbidity
and mortality, the data on long-term outcomes are much less complete.
- This study is designed to prospectively evaluate the effects of unilateral nephrectomy
on cardiovascular-renal functions of donors after living kidney donation: the
development of hypertension, albuminuria, renal failure, inflammatory and endothelial
changes.
Renal dysfunction is associated with accelerated cardiovascular disease even when kidney
function is only mildly impaired. Besides, even levels of urinary albumin excretion below
the accepted threshold for microalbuminuria are associated with increased cardiovascular
risk, and the risk increases as the degree of proteinuria rises.
- Live-donor kidney transplantation is generally considered the best choice for patients
who have renal failure and are awaiting transplantation, because these kidneys function
better than kidneys from deceased donors, and waiting times for deceased-donor
transplants are long. Although several studies have shown that kidney donation has low
short-term morbidity and mortality, the data on long-term outcomes are much less
complete. The short and long term renal functions of donors after kidney donation were
much studied and still remain uncertain, the cardiovascular effects of reduction in
renal mass in kidney donors is also not clearly known.
- Endothelial dysfunction (ED) is the first step for subsequent development of
atherosclerosis, which can help us to assess the cardiovascular changes after kidney
donation. Prospectively examining the endothelial consequences of uninephrectomy in
donors may provide useful insight into the existence and pathophysiology of
cardiovascular disease in donors and, therefore, into how the cardiovascular disease
risk associated with renal impairment might eventually be reduced.
;
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