Effectiveness and Tolerability of Tarka® in the Treatment of Hypertensive Patients With High Risk of Developing Diabetes Mellitus

Hypertension Clinical Trial

— TARDIA  

Official title:

Effectiveness and Tolerability of Tarka in the Treatment of Hypertensive Patients With High Risk of Developing Diabetes Mellitus, Not Controlled on Single-drug Therapy: A Multicountry, Multicenter, Post-marketing Observational Study in the Routine Clinical Use

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01079195
• Other study ID #: P10-299
• Status: Completed
• Phase: N/A
• First received: March 1, 2010
• Last updated: April 15, 2011
• Start date: October 2007
• Est. completion date: March 2010

Study information

• Verified date: April 2011
• Source: Abbott
• Contact: n/a
• Is FDA regulated: No
• Health authority: Romania: Ethics CommitteeBulgaria: Bulgarian Drug AgencyBulgaria: Ministry of HealthSlovakia: State Institute for Drug ControlSlovak Republic: Ethics CommitteeUkraine: State Pharmacological Center - Ministry of HealthUkraine: Ministry of HealthRussia: Ministry of Health of the Russian FederationRussia: Ethics CommitteeRussia: FSI Scientific Center of Expertise of Medical ApplicationCzech Republic: State Institute for Drug ControlSlovenia: Ethics CommitteeSlovenia: Ministry of Health
• Study type: Observational

Clinical Trial Summary

The aim of this post-marketing observational study (PMOS) is to provide data on the effectiveness and tolerability of Tarka in patients with a high risk of developing diabetes mellitus, as prescribed by the physicians in a community setting and in accordance with the terms of the local marketing authorization. The following specific questions will be addressed:

• Effectiveness of Tarka in lowering the blood pressure in hypertensive patients being at high risk of developing diabetes, not controlled on single-drug therapy.

• Tolerability of Tarka as assessed by withdrawal rates.

Description:

This is a non-interventional, observational, open-label, multicountry, multicenter post-marketing study in which Tarka is prescribed in the usual manner in accordance with the terms of the local market authorization with regards to dose, population and indication. Patients with a high risk of developing diabetes mellitus treated by secondary care specialists (such as internal medicine specialists, nephrologists, endocrinologists, etc.), whose hypertension is not controlled on single-drug therapy will be included.

The assignment of the patient to the treatment with Tarka is not decided in advance by this protocol but falls within current practice. The prescription of Tarka is clearly separated from the decision to include the patient in this study. No additional procedures (other than standard of care) shall be applied to the patients.

Each patient will be treated at the physician's discretion. Dosing schedule should be in the accordance with the locally approved Summary of Product Characteristics (SmPC). Physicians will be provided with a study kit that includes a protocol, Tarka's locally approved SmPC, and case reports forms for each patient to be enrolled.

The patient's demographic data, height, weight and waist circumference will be reported in the Inclusion visit. The previous antihypertensive therapy should be noted (generic name of the drug and total daily dose). All other drugs the patient currently receives for cardiovascular disease treatment should be recorded as well.

The patient will then be followed via regular office visits as determined by the physician. As this study is observational in nature, patient follow-up is not interventional and is left to the judgment of each physician within the 6-month period, which defines the survey for each patient. For indicative purposes, follow-up of participant should enable 3 patient visits during this period. For these reasons, the most likely visits are defined as "Inclusion visit" at which treatment with Tarka is to be commenced, and then "Follow-up visit Month 3 " and "Follow-up visit Month 6", although dates will depend only on the decision of the physician. As a result, failure to meet these suggested dates will not constitute a breach of the protocol.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15436
• Est. completion date: March 2010
• Est. primary completion date: March 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult patients of either gender (more than 18 years of age), with established diagnosis of essential hypertension (systolic blood pressure/ diastolic blood pressure greater than 140/90 mmHg)

• Patients not controlled on single-drug therapy and decision was made to introduce Tarka

• Patients with a high risk of developing diabetes mellitus (defined according British Medical Society guidelines) with at least one of the following symptoms:

• Positive family history of diabetes or

• Obesity defined by a Body Mass Index (BMI) greater than 30 kg/m^2 or a waist circumference greater than 102 cm (males) or greater than 88 cm (females) or

• Impaired fasting plasma glucose (FPG) levels of 6.1 to 7.0 mmol/l (100-126 mg/dl)

Exclusion Criteria:

• Patients with known or established Type 2 diabetes mellitus

• The use of Tarka is contraindicated in the following patients:

• Hypersensitive to the active substances or to any of the inactive ingredients

• With cardiogenic shock

• With second and third degree atrioventricular block - except in patients with a functioning artificial pacemaker

• With sick sinus syndrome - except in patients with a functioning artificial pacemaker

• With atrial fibrillation/flutter and concomitant Wolff-Parkinson-White syndrome

• With existing history of angioedema associated with administration of an angiotensin-converting enzyme (ACE) inhibitor

• With severe renal or severe liver impairment

• In pregnant women (women of childbearing potential who are unwilling to use contraception should not be included)

• Lactating women

Study Design

N/A

Related Conditions & MeSH terms

• Diabetes Mellitus
• Hypertension

Locations

Country	Name	City	State
Bulgaria	Site Reference ID/Investigator# 29197	Haskovo
Bulgaria	Site Reference ID/Investigator# 29685	Pleven
Bulgaria	Site Reference ID/Investigator# 29682	Plovdiv
Bulgaria	Site Reference ID/Investigator# 29686	Plovdiv
Bulgaria	Site Reference ID/Investigator# 28954	Sofia
Bulgaria	Site Reference ID/Investigator# 29079	Sofia
Bulgaria	Site Reference ID/Investigator# 29097	Sofia
Bulgaria	Site Reference ID/Investigator# 29651	Sofia
Bulgaria	Site Reference ID/Investigator# 29681	Sofia
Bulgaria	Site Reference ID/Investigator# 29683	Sofia
Bulgaria	Site Reference ID/Investigator# 29484	Stara Zagora
Bulgaria	Site Reference ID/Investigator# 29485	Stara Zagora
Bulgaria	Site Reference ID/Investigator# 29480	Varna
Bulgaria	Site Reference ID/Investigator# 7568	Varna
Bulgaria	Site Reference ID/Investigator# 29196	Veliko Turnovo
Czech Republic	Site Reference ID/Investigator# 28887	Adamov
Czech Republic	Site Reference ID/Investigator# 28660	As
Czech Republic	Site Reference ID/Investigator# 28705	As
Czech Republic	Site Reference ID/Investigator# 28726	Bilina
Czech Republic	Site Reference ID/Investigator# 29013	Bilina
Czech Republic	Site Reference ID/Investigator# 29146	Bilina
Czech Republic	Site Reference ID/Investigator# 29070	Bohumin
Czech Republic	Site Reference ID/Investigator# 28891	Bolatice
Czech Republic	Site Reference ID/Investigator# 28803	Borsov nad Vltavou
Czech Republic	Site Reference ID/Investigator# 29047	Boskovice
Czech Republic	Site Reference ID/Investigator# 29108	Brandysek
Czech Republic	Site Reference ID/Investigator# 28843	Brasy-Stupno
Czech Republic	Site Reference ID/Investigator# 28646	Breclav
Czech Republic	Site Reference ID/Investigator# 28578	Brno
Czech Republic	Site Reference ID/Investigator# 28706	Brno
Czech Republic	Site Reference ID/Investigator# 28737	Brno
Czech Republic	Site Reference ID/Investigator# 28759	Brno
Czech Republic	Site Reference ID/Investigator# 28908	Brno
Czech Republic	Site Reference ID/Investigator# 28914	Brno
Czech Republic	Site Reference ID/Investigator# 28971	Brno
Czech Republic	Site Reference ID/Investigator# 28972	Brno
Czech Republic	Site Reference ID/Investigator# 28973	Brno
Czech Republic	Site Reference ID/Investigator# 29036	Brno
Czech Republic	Site Reference ID/Investigator# 29043	Brno
Czech Republic	Site Reference ID/Investigator# 29044	Brno
Czech Republic	Site Reference ID/Investigator# 29117	Brno
Czech Republic	Site Reference ID/Investigator# 29123	Brno
Czech Republic	Site Reference ID/Investigator# 29124	Brno
Czech Republic	Site Reference ID/Investigator# 29134	Brno
Czech Republic	Site Reference ID/Investigator# 29173	Brno
Czech Republic	Site Reference ID/Investigator# 29175	Brno
Czech Republic	Site Reference ID/Investigator# 29693	Broumov
Czech Republic	Site Reference ID/Investigator# 29694	Broumov
Czech Republic	Site Reference ID/Investigator# 28874	Bustehrad
Czech Republic	Site Reference ID/Investigator# 29136	Celakovice
Czech Republic	Site Reference ID/Investigator# 28814	Cernosin
Czech Republic	Site Reference ID/Investigator# 29069	Cervena Voda
Czech Republic	Site Reference ID/Investigator# 28900	Ceska Trebova
Czech Republic	Site Reference ID/Investigator# 28634	Ceske Budejovice
Czech Republic	Site Reference ID/Investigator# 28651	Ceske Budejovice
Czech Republic	Site Reference ID/Investigator# 28798	Ceske Budejovice
Czech Republic	Site Reference ID/Investigator# 28877	Ceske Budejovice
Czech Republic	Site Reference ID/Investigator# 29118	Cesky Tesin
Czech Republic	Site Reference ID/Investigator# 28684	Cheb
Czech Republic	Site Reference ID/Investigator# 28751	Cheb
Czech Republic	Site Reference ID/Investigator# 28847	Cheb
Czech Republic	Site Reference ID/Investigator# 29132	Cheb
Czech Republic	Site Reference ID/Investigator# 29142	Cheb
Czech Republic	Site Reference ID/Investigator# 28669	Chomutov
Czech Republic	Site Reference ID/Investigator# 28732	Chrudim
Czech Republic	Site Reference ID/Investigator# 28792	Chrudim
Czech Republic	Site Reference ID/Investigator# 29017	Chrudim
Czech Republic	Site Reference ID/Investigator# 28854	Cista
Czech Republic	Site Reference ID/Investigator# 28696	Decin
Czech Republic	Site Reference ID/Investigator# 28748	Decin
Czech Republic	Site Reference ID/Investigator# 28852	Decin
Czech Republic	Site Reference ID/Investigator# 28936	Dolni Kalna
Czech Republic	Site Reference ID/Investigator# 28786	Domazlice
Czech Republic	Site Reference ID/Investigator# 28821	Domazlice
Czech Republic	Site Reference ID/Investigator# 29021	Domazlice
Czech Republic	Site Reference ID/Investigator# 28855	Duchcov
Czech Republic	Site Reference ID/Investigator# 29139	Frenstat pod Radhostem
Czech Republic	Site Reference ID/Investigator# 29158	Frydek-Mistek
Czech Republic	Site Reference ID/Investigator# 28682	Frydlant nad Ostravici
Czech Republic	Site Reference ID/Investigator# 28817	Havirov
Czech Republic	Site Reference ID/Investigator# 28657	Havlickuv Brod
Czech Republic	Site Reference ID/Investigator# 28733	Havlickuv Brod
Czech Republic	Site Reference ID/Investigator# 28858	Hnevotin
Czech Republic	Site Reference ID/Investigator# 28904	Horsovsky Tyn
Czech Republic	Site Reference ID/Investigator# 28894	Hostinne
Czech Republic	Site Reference ID/Investigator# 28665	Hranice
Czech Republic	Site Reference ID/Investigator# 28700	Hranice
Czech Republic	Site Reference ID/Investigator# 28809	Hranice
Czech Republic	Site Reference ID/Investigator# 28933	Hranice
Czech Republic	Site Reference ID/Investigator# 28861	Jablonec nad Nisou
Czech Republic	Site Reference ID/Investigator# 29155	Jablonec nad Nisou
Czech Republic	Site Reference ID/Investigator# 28630	Javornik
Czech Republic	Site Reference ID/Investigator# 28648	Jihlava
Czech Republic	Site Reference ID/Investigator# 28756	Jihlava
Czech Republic	Site Reference ID/Investigator# 28836	Jihlava
Czech Republic	Site Reference ID/Investigator# 28643	Jindrichuv Hradec
Czech Republic	Site Reference ID/Investigator# 28788	Jindrichuv Hradec
Czech Republic	Site Reference ID/Investigator# 28678	Karlovy Vary
Czech Republic	Site Reference ID/Investigator# 28741	Karlovy Vary
Czech Republic	Site Reference ID/Investigator# 28893	Karlovy Vary
Czech Republic	Site Reference ID/Investigator# 28652	Kdyne
Czech Republic	Site Reference ID/Investigator# 28796	Kladeruby
Czech Republic	Site Reference ID/Investigator# 28645	Kladno
Czech Republic	Site Reference ID/Investigator# 28916	Kladno
Czech Republic	Site Reference ID/Investigator# 28647	Klatovy
Czech Republic	Site Reference ID/Investigator# 28659	Klatovy
Czech Republic	Site Reference ID/Investigator# 28773	Kolin
Czech Republic	Site Reference ID/Investigator# 29156	Kolin
Czech Republic	Site Reference ID/Investigator# 29393	Krnov
Czech Republic	Site Reference ID/Investigator# 28872	Kromeriz
Czech Republic	Site Reference ID/Investigator# 28760	Kunovice
Czech Republic	Site Reference ID/Investigator# 28857	Kutna Hora
Czech Republic	Site Reference ID/Investigator# 28886	Kutna Hora
Czech Republic	Site Reference ID/Investigator# 28655	Lazne Belohrad
Czech Republic	Site Reference ID/Investigator# 28898	Lednice
Czech Republic	Site Reference ID/Investigator# 29019	Liberec
Czech Republic	Site Reference ID/Investigator# 29141	Libice nad Cidlinou
Czech Republic	Site Reference ID/Investigator# 28723	Libusin
Czech Republic	Site Reference ID/Investigator# 29153	Lipnik nad Becvou
Czech Republic	Czech Republic Site Reference ID/Investigator# 28769	Litomerice
Czech Republic	Site Reference ID/Investigator# 28815	Litomerice
Czech Republic	Site Reference ID/Investigator# 29116	Litomysl
Czech Republic	Site Reference ID/Investigator# 29020	Lovosice
Czech Republic	Site Reference ID/Investigator# 28650	Marianske Lazne
Czech Republic	Site Reference ID/Investigator# 28878	Melnik
Czech Republic	Site Reference ID/Investigator# 29149	Mestec Kralove
Czech Republic	Site Reference ID/Investigator# 28820	Mikulov
Czech Republic	Site Reference ID/Investigator# 28824	Mimon
Czech Republic	Site Reference ID/Investigator# 28853	Mnichovo Hradiste
Czech Republic	Site Reference ID/Investigator# 28867	Mohelnice
Czech Republic	Site Reference ID/Investigator# 29361	Mohelnice
Czech Republic	Site Reference ID/Investigator# 28662	Nachod
Czech Republic	Site Reference ID/Investigator# 29128	Neratovice
Czech Republic	Site Reference ID/Investigator# 29057	Nove Mesto nad Metuji
Czech Republic	Site Reference ID/Investigator# 28888	Novy Bor
Czech Republic	Site Reference ID/Investigator# 28875	Novy bydzov
Czech Republic	Site Reference ID/Investigator# 28740	Nymburk
Czech Republic	Site Reference ID/Investigator# 29689	Olomouc
Czech Republic	Site Reference ID/Investigator# 29692	Olomouc
Czech Republic	Site Reference ID/Investigator# 29695	Olomouc
Czech Republic	Site Reference ID/Investigator# 29121	Opava
Czech Republic	Site Reference ID/Investigator# 29688	Opocno
Czech Republic	Site Reference ID/Investigator# 29071	Orlova
Czech Republic	Site Reference ID/Investigator# 28664	Ostrava
Czech Republic	Site Reference ID/Investigator# 28679	Ostrava
Czech Republic	Site Reference ID/Investigator# 28681	Ostrava
Czech Republic	Site Reference ID/Investigator# 28708	Ostrava
Czech Republic	Site Reference ID/Investigator# 28711	Ostrava
Czech Republic	Site Reference ID/Investigator# 28746	Ostrava
Czech Republic	Site Reference ID/Investigator# 28755	Ostrava
Czech Republic	Site Reference ID/Investigator# 28787	Ostrava
Czech Republic	Site Reference ID/Investigator# 28807	Ostrava
Czech Republic	Site Reference ID/Investigator# 28816	Ostrava
Czech Republic	Site Reference ID/Investigator# 28863	Ostrava
Czech Republic	Site Reference ID/Investigator# 28868	Ostrava
Czech Republic	Site Reference ID/Investigator# 29014	Ostrava
Czech Republic	Site Reference ID/Investigator# 29046	Ostrava
Czech Republic	Site Reference ID/Investigator# 29113	Ostrava
Czech Republic	Site Reference ID/Investigator# 29152	Ostrava
Czech Republic	Site Reference ID/Investigator# 29690	Ostrava
Czech Republic	Site Reference ID/Investigator# 29691	Ostrava
Czech Republic	Site Reference ID/Investigator# 28905	Ostrava-Hostalkovice
Czech Republic	Site Reference ID/Investigator# 28780	Ostrava-Krasne Pole
Czech Republic	Site Reference ID/Investigator# 28663	Ostrava-Poruba
Czech Republic	Site Reference ID/Investigator# 28902	Ostrov
Czech Republic	Site Reference ID/Investigator# 28728	Otrokovice
Czech Republic	Site Reference ID/Investigator# 28661	Pardubice
Czech Republic	Site Reference ID/Investigator# 28668	Pardubice
Czech Republic	Site Reference ID/Investigator# 28735	Pardubice
Czech Republic	Site Reference ID/Investigator# 28742	Pardubice
Czech Republic	Site Reference ID/Investigator# 28770	Pardubice
Czech Republic	Site Reference ID/Investigator# 28776	Pardubice
Czech Republic	Site Reference ID/Investigator# 28789	Pardubice
Czech Republic	Site Reference ID/Investigator# 28845	Pardubice
Czech Republic	Site Reference ID/Investigator# 28873	Pardubice
Czech Republic	Site Reference ID/Investigator# 28964	Pardubice
Czech Republic	Site Reference ID/Investigator# 29120	Pardubice
Czech Republic	Site Reference ID/Investigator# 28777	Paseka
Czech Republic	Site Reference ID/Investigator# 28615	Pelhrimov
Czech Republic	Site Reference ID/Investigator# 28675	Pelhrimov
Czech Republic	Site Reference ID/Investigator# 28844	Pisek
Czech Republic	Site Reference ID/Investigator# 29143	Pisek
Czech Republic	Site Reference ID/Investigator# 29115	Plana nad Luznici
Czech Republic	Site Reference ID/Investigator# 28670	Plzen
Czech Republic	Site Reference ID/Investigator# 28680	Plzen
Czech Republic	Site Reference ID/Investigator# 28683	Plzen
Czech Republic	Site Reference ID/Investigator# 28685	Plzen
Czech Republic	Site Reference ID/Investigator# 28752	Plzen
Czech Republic	Site Reference ID/Investigator# 28785	Plzen
Czech Republic	Site Reference ID/Investigator# 28827	Plzen
Czech Republic	Site Reference ID/Investigator# 28931	Plzen
Czech Republic	Site Reference ID/Investigator# 29145	Plzen
Czech Republic	Site Reference ID/Investigator# 28676	Policka
Czech Republic	Site Reference ID/Investigator# 28658	Postoloprty
Czech Republic	Site Reference ID/Investigator# 28833	Prachatice
Czech Republic	Site Reference ID/Investigator# 28774	Prague
Czech Republic	Site Reference ID/Investigator# 29131	Prague
Czech Republic	Site Reference ID/Investigator# 28802	Prague 1
Czech Republic	Site Reference ID/Investigator# 28623	Prague 10
Czech Republic	Site Reference ID/Investigator# 28633	Prague 10
Czech Republic	Site Reference ID/Investigator# 28656	Prague 10
Czech Republic	Site Reference ID/Investigator# 28692	Prague 10
Czech Republic	Site Reference ID/Investigator# 28698	Prague 10
Czech Republic	Site Reference ID/Investigator# 28703	Prague 10
Czech Republic	Site Reference ID/Investigator# 28801	Prague 10
Czech Republic	Site Reference ID/Investigator# 28842	Prague 10
Czech Republic	Site Reference ID/Investigator# 29060	Prague 10
Czech Republic	Site Reference ID/Investigator# 29696	Prague 2
Czech Republic	Site Reference ID/Investigator# 28790	Prague 3
Czech Republic	Site Reference ID/Investigator# 28876	Prague 3
Czech Republic	Site Reference ID/Investigator# 28631	Prague 4
Czech Republic	Site Reference ID/Investigator# 28635	Prague 4
Czech Republic	Site Reference ID/Investigator# 28687	Prague 4
Czech Republic	Site Reference ID/Investigator# 28767	Prague 4
Czech Republic	Site Reference ID/Investigator# 28794	Prague 4
Czech Republic	Site Reference ID/Investigator# 28797	Prague 4
Czech Republic	Site Reference ID/Investigator# 28826	Prague 4
Czech Republic	Site Reference ID/Investigator# 28831	Prague 4
Czech Republic	Site Reference ID/Investigator# 28864	Prague 4
Czech Republic	Site Reference ID/Investigator# 28926	Prague 4
Czech Republic	Site Reference ID/Investigator# 29376	Prague 4
Czech Republic	Site Reference ID/Investigator# 29377	Prague 4
Czech Republic	Site Reference ID/Investigator# 28617	Prague 5
Czech Republic	Site Reference ID/Investigator# 28627	Prague 5
Czech Republic	Site Reference ID/Investigator# 28649	Prague 5
Czech Republic	Site Reference ID/Investigator# 28813	Prague 5
Czech Republic	Site Reference ID/Investigator# 28840	Prague 5
Czech Republic	Site Reference ID/Investigator# 29127	Prague 5
Czech Republic	Site Reference ID/Investigator# 29396	Prague 5
Czech Republic	Site Reference ID/Investigator# 29687	Prague 5
Czech Republic	Site Reference ID/Investigator# 28913	Prague 6
Czech Republic	Site Reference ID/Investigator# 28765	Prague 7
Czech Republic	Site Reference ID/Investigator# 28928	Prague 7
Czech Republic	Site Reference ID/Investigator# 28653	Prague 8
Czech Republic	Site Reference ID/Investigator# 28724	Prague 8
Czech Republic	Site Reference ID/Investigator# 28823	Prague 8
Czech Republic	Site Reference ID/Investigator# 28673	Prague 9
Czech Republic	Site Reference ID/Investigator# 28795	Prague 9
Czech Republic	Site Reference ID/Investigator# 28882	Prague 9
Czech Republic	Site Reference ID/Investigator# 28911	Prague 9
Czech Republic	Site Reference ID/Investigator# 28935	Prague 9
Czech Republic	Site Reference ID/Investigator# 29150	Prague 9
Czech Republic	Site Reference ID/Investigator# 28701	Prelouc
Czech Republic	Site Reference ID/Investigator# 28822	Prelouc
Czech Republic	Site Reference ID/Investigator# 28719	Prerov
Czech Republic	Site Reference ID/Investigator# 28783	Pribram
Czech Republic	Site Reference ID/Investigator# 29022	Pribram V-Zdabor
Czech Republic	Site Reference ID/Investigator# 28750	Primda
Czech Republic	Site Reference ID/Investigator# 29111	Prostejov
Czech Republic	Site Reference ID/Investigator# 29418	Prostejov
Czech Republic	Site Reference ID/Investigator# 29420	Prostejov
Czech Republic	Site Reference ID/Investigator# 28707	Rakovnik
Czech Republic	Site Reference ID/Investigator# 28768	Rakovnik
Czech Republic	Site Reference ID/Investigator# 29024	Rakovnik
Czech Republic	Site Reference ID/Investigator# 28846	Revnice
Czech Republic	Site Reference ID/Investigator# 29300	Revnice
Czech Republic	Site Reference ID/Investigator# 28714	Rosice
Czech Republic	Site Reference ID/Investigator# 7575	Rosice
Czech Republic	Site Reference ID/Investigator# 28772	Roznov pod Radhostem
Czech Republic	Site Reference ID/Investigator# 29137	Roznov pod Radhostem
Czech Republic	Site Reference ID/Investigator# 28674	Rybitvi
Czech Republic	Site Reference ID/Investigator# 28848	Sezimovo Usti
Czech Republic	Site Reference ID/Investigator# 28866	Sezimovo Usti
Czech Republic	Site Reference ID/Investigator# 29122	Slany
Czech Republic	Site Reference ID/Investigator# 28712	Slavicin
Czech Republic	Site Reference ID/Investigator# 28628	Sokolov
Czech Republic	Site Reference ID/Investigator# 28860	Sokolov
Czech Republic	Site Reference ID/Investigator# 28791	Stepankovice
Czech Republic	Site Reference ID/Investigator# 28890	Sumperk
Czech Republic	Site Reference ID/Investigator# 29066	Sumperk
Czech Republic	Site Reference ID/Investigator# 29067	Svitavy
Czech Republic	Site Reference ID/Investigator# 28677	Tabor
Czech Republic	Site Reference ID/Investigator# 28710	Tabor
Czech Republic	Site Reference ID/Investigator# 28672	Telc
Czech Republic	Site Reference ID/Investigator# 28704	Teplice
Czech Republic	Site Reference ID/Investigator# 28811	Teplice
Czech Republic	Site Reference ID/Investigator# 28862	Teplice
Czech Republic	Site Reference ID/Investigator# 28616	Trebic
Czech Republic	Site Reference ID/Investigator# 28912	Trebic
Czech Republic	Site Reference ID/Investigator# 29126	Trebic
Czech Republic	Site Reference ID/Investigator# 28758	Trhove Sviny
Czech Republic	Site Reference ID/Investigator# 29157	Trinec-Kanada
Czech Republic	Site Reference ID/Investigator# 28899	Trutnov
Czech Republic	Site Reference ID/Investigator# 29110	Trutnov
Czech Republic	Site Reference ID/Investigator# 28739	Turnov
Czech Republic	Site Reference ID/Investigator# 28747	Turnov
Czech Republic	Site Reference ID/Investigator# 28925	Tyn nad Vltavou
Czech Republic	Site Reference ID/Investigator# 28927	Tyn nad Vltavou
Czech Republic	Site Reference ID/Investigator# 29151	Uherske Hradiste
Czech Republic	Site Reference ID/Investigator# 28636	Ujezd u Brna
Czech Republic	Site Reference ID/Investigator# 29135	Ujezd u Brna
Czech Republic	Site Reference ID/Investigator# 28699	Usti nad Labem
Czech Republic	Site Reference ID/Investigator# 28869	Usti nad Labem
Czech Republic	Site Reference ID/Investigator# 29114	Usti nad Orlici
Czech Republic	Site Reference ID/Investigator# 28709	Valasske Klobouky
Czech Republic	Site Reference ID/Investigator# 28654	Valasske Mezirici
Czech Republic	Site Reference ID/Investigator# 28865	Valasske Mezirici
Czech Republic	Site Reference ID/Investigator# 29112	Valasske Mezirici
Czech Republic	Site Reference ID/Investigator# 29144	Valasske Mezirici
Czech Republic	Site Reference ID/Investigator# 28818	Vamberk
Czech Republic	Site Reference ID/Investigator# 28895	Velke Hamry
Czech Republic	Site Reference ID/Investigator# 29390	Vintirov
Czech Republic	Site Reference ID/Investigator# 28713	Visnova
Czech Republic	Site Reference ID/Investigator# 28624	Vlasim
Czech Republic	Site Reference ID/Investigator# 29025	Vodnany
Czech Republic	Site Reference ID/Investigator# 29018	Votice-Otradovice
Czech Republic	Site Reference ID/Investigator# 29148	Vratimov
Czech Republic	Site Reference ID/Investigator# 28666	Vsetin
Czech Republic	Site Reference ID/Investigator# 28856	Vsetin
Czech Republic	Site Reference ID/Investigator# 29109	Vsetin
Czech Republic	Site Reference ID/Investigator# 29049	Vysoke Myto
Czech Republic	Site Reference ID/Investigator# 28837	Zabreh na Morave
Czech Republic	Site Reference ID/Investigator# 28697	Zahradky
Czech Republic	Site Reference ID/Investigator# 28962	Zamberk
Czech Republic	Site Reference ID/Investigator# 28906	Zd'ar
Czech Republic	Site Reference ID/Investigator# 29048	Zirovnice
Czech Republic	Site Reference ID/Investigator# 28781	Znojmo
Czech Republic	Site Reference ID/Investigator# 28804	Znojmo
Czech Republic	Site Reference ID/Investigator# 28924	Znojmo
Romania	Site Reference ID/Investigator# 28575	Alba-Iulia
Romania	Site Reference ID/Investigator# 28580	Bacau
Romania	Site Reference ID/Investigator# 28581	Bacau
Romania	Site Reference ID/Investigator# 29749	Baia Mare
Romania	Site Reference ID/Investigator# 29077	Brasov
Romania	Site Reference ID/Investigator# 28605	Bucharest
Romania	Site Reference ID/Investigator# 28577	Bucuresti
Romania	Site Reference ID/Investigator# 28955	Bucuresti
Romania	Site Reference ID/Investigator# 28982	Bucuresti
Romania	Site Reference ID/Investigator# 29072	Bucuresti
Romania	Site Reference ID/Investigator# 29073	Bucuresti
Romania	Site Reference ID/Investigator# 32095	Bucuresti
Romania	Site Reference ID/Investigator# 32096	Bucuresti
Romania	Site Reference ID/Investigator# 28583	Buzau
Romania	Site Reference ID/Investigator# 32109	Cluj Napoca
Romania	Site Reference ID/Investigator# 32110	Cluj Napoca
Romania	Site Reference ID/Investigator# 32111	Cluj Napoca
Romania	Site Reference ID/Investigator# 28579	Constanta
Romania	Site Reference ID/Investigator# 28584	Constanta
Romania	Site Reference ID/Investigator# 29099	Constanta
Romania	Site Reference ID/Investigator# 28992	Covasna
Romania	Site Reference ID/Investigator# 28613	Giurgiu
Romania	Site Reference ID/Investigator# 28602	Iasi
Romania	Site Reference ID/Investigator# 28967	Iasi
Romania	Site Reference ID/Investigator# 29074	Iasi
Romania	Site Reference ID/Investigator# 28961	Odorheiu Secuiesc
Romania	Site Reference ID/Investigator# 28963	Oradea
Romania	Site Reference ID/Investigator# 29752	Oradea
Romania	Site Reference ID/Investigator# 28995	Pitesti
Romania	Site Reference ID/Investigator# 29628	Pitesti
Romania	Site Reference ID/Investigator# 29629	Pitesti
Romania	Site Reference ID/Investigator# 29031	Ploiesti
Romania	Site Reference ID/Investigator# 29191	Resita
Romania	Site Reference ID/Investigator# 6369	Sibiu
Romania	Site Reference ID/Investigator# 29006	Suceava
Romania	Site Reference ID/Investigator# 29088	Targoviste
Romania	Site Reference ID/Investigator# 29089	Targu Mures
Romania	Site Reference ID/Investigator# 29330	Targu Mures
Romania	Site Reference ID/Investigator# 29331	Targu Mures
Romania	Site Reference ID/Investigator# 29032	Tg. Mures
Romania	Site Reference ID/Investigator# 29086	Timisoara
Romania	Site Reference ID/Investigator# 29087	Timisoara
Russian Federation	Site Reference ID/Investigator# 28596	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 28986	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 29248	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 29332	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 29546	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 29547	Chelyabinsk
Russian Federation	Site Reference ID/Investigator# 29491	Dmitrov
Russian Federation	Site Reference ID/Investigator# 29492	Dmitrov
Russian Federation	Site Reference ID/Investigator# 29404	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29405	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29406	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29411	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29412	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29414	Ekaterinburg
Russian Federation	Site Reference ID/Investigator# 29496	Ivanteyevka
Russian Federation	Site Reference ID/Investigator# 29221	Kazan
Russian Federation	Site Reference ID/Investigator# 29256	Kazan
Russian Federation	Site Reference ID/Investigator# 29423	Kazan
Russian Federation	Site Reference ID/Investigator# 29427	Kazan
Russian Federation	Site Reference ID/Investigator# 29562	Kazan
Russian Federation	Site Reference ID/Investigator# 29649	Kazan
Russian Federation	Site Reference ID/Investigator# 29650	Kazan
Russian Federation	Site Reference ID/Investigator# 28597	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29162	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29189	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29326	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29343	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29429	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29431	Kemerovo
Russian Federation	Site Reference ID/Investigator# 29498	Khimki
Russian Federation	Site Reference ID/Investigator# 28598	Korolev
Russian Federation	Site Reference ID/Investigator# 29499	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29500	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29501	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29502	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29503	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29504	Krasnodar
Russian Federation	Site Reference ID/Investigator# 29527	Krasnogorsk
Russian Federation	Site Reference ID/Investigator# 29530	Krasnogorsk
Russian Federation	Site Reference ID/Investigator# 28979	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 28981	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29174	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29209	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29444	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29446	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29448	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29449	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29451	Krasnoyarsk
Russian Federation	Site Reference ID/Investigator# 29169	Lipetsk
Russian Federation	Site Reference ID/Investigator# 29231	Lipetsk
Russian Federation	Site Reference ID/Investigator# 28593	Moscow
Russian Federation	Site Reference ID/Investigator# 28940	Moscow
Russian Federation	Site Reference ID/Investigator# 28941	Moscow
Russian Federation	Site Reference ID/Investigator# 28949	Moscow
Russian Federation	Site Reference ID/Investigator# 28980	Moscow
Russian Federation	Site Reference ID/Investigator# 29078	Moscow
Russian Federation	Site Reference ID/Investigator# 29181	Moscow
Russian Federation	Site Reference ID/Investigator# 29185	Moscow
Russian Federation	Site Reference ID/Investigator# 29194	Moscow
Russian Federation	Site Reference ID/Investigator# 29205	Moscow
Russian Federation	Site Reference ID/Investigator# 29216	Moscow
Russian Federation	Site Reference ID/Investigator# 29220	Moscow
Russian Federation	Site Reference ID/Investigator# 29223	Moscow
Russian Federation	Site Reference ID/Investigator# 29227	Moscow
Russian Federation	Site Reference ID/Investigator# 29237	Moscow
Russian Federation	Site Reference ID/Investigator# 29561	Moscow
Russian Federation	Site Reference ID/Investigator# 29602	Moscow
Russian Federation	Site Reference ID/Investigator# 29603	Moscow
Russian Federation	Site Reference ID/Investigator# 29621	Moscow
Russian Federation	Site Reference ID/Investigator# 29625	Mytischi
Russian Federation	Site Reference ID/Investigator# 29532	N.Novgorod
Russian Federation	Site Reference ID/Investigator# 29533	N.Novgorod
Russian Federation	Site Reference ID/Investigator# 29534	N.Novgorod
Russian Federation	Site Reference ID/Investigator# 29535	N.Novgorod
Russian Federation	Site Reference ID/Investigator# 29634	N.Novgorod
Russian Federation	Site Reference ID/Investigator# 29182	Novokuibyshevsk
Russian Federation	Site Reference ID/Investigator# 29226	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29536	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29568	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29619	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29627	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29647	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 29648	Novosibirsk
Russian Federation	Site Reference ID/Investigator# 28592	Omsk
Russian Federation	Site Reference ID/Investigator# 28976	Omsk
Russian Federation	Site Reference ID/Investigator# 28977	Omsk
Russian Federation	Site Reference ID/Investigator# 29335	Omsk
Russian Federation	Site Reference ID/Investigator# 29337	Omsk
Russian Federation	Site Reference ID/Investigator# 29338	Omsk
Russian Federation	Site Reference ID/Investigator# 29339	Omsk
Russian Federation	Site Reference ID/Investigator# 29537	Omsk
Russian Federation	Site Reference ID/Investigator# 29622	Omsk
Russian Federation	Site Reference ID/Investigator# 29511	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 29512	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 29513	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 29514	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 29515	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 29516	Rostov-na-Donu
Russian Federation	Site Reference ID/Investigator# 28604	Samara
Russian Federation	Site Reference ID/Investigator# 28987	Samara
Russian Federation	Site Reference ID/Investigator# 29183	Samara
Russian Federation	Site Reference ID/Investigator# 29187	Samara
Russian Federation	Site Reference ID/Investigator# 29201	Samara
Russian Federation	Site Reference ID/Investigator# 29202	Samara
Russian Federation	Site Reference ID/Investigator# 29203	Samara
Russian Federation	Site Reference ID/Investigator# 29222	Samara
Russian Federation	Site Reference ID/Investigator# 29253	Samara
Russian Federation	Site Reference ID/Investigator# 29276	Samara
Russian Federation	Site Reference ID/Investigator# 29277	Samara
Russian Federation	Site Reference ID/Investigator# 29474	Samara
Russian Federation	Site Reference ID/Investigator# 29475	Samara
Russian Federation	Site Reference ID/Investigator# 29476	Samara
Russian Federation	Site Reference ID/Investigator# 29523	Samara
Russian Federation	Site Reference ID/Investigator# 29524	Samara
Russian Federation	Site Reference ID/Investigator# 29539	Samara
Russian Federation	Site Reference ID/Investigator# 29540	Samara
Russian Federation	Site Reference ID/Investigator# 29541	Samara
Russian Federation	Site Reference ID/Investigator# 29543	Samara
Russian Federation	Site Reference ID/Investigator# 29616	Samara
Russian Federation	Site Reference ID/Investigator# 29617	Samara
Russian Federation	Site Reference ID/Investigator# 29641	Samara
Russian Federation	Site Reference ID/Investigator# 29643	Samara
Russian Federation	Site Reference ID/Investigator# 29644	Samara
Russian Federation	Site Reference ID/Investigator# 29544	Shchelkovo
Russian Federation	Site Reference ID/Investigator# 29487	St. Petersburg
Russian Federation	Site Reference ID/Investigator# 33322	St. Petersburg
Russian Federation	Site Reference ID/Investigator# 28594	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 28603	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 28942	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29178	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29200	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29210	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29213	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29217	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29246	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29341	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29342	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29349	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29457	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29471	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29472	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29473	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29486	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29488	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29549	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29553	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29554	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29575	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29576	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29584	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29589	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29590	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29592	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29594	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29595	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29611	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29614	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 29615	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 6368	St.Petersburg
Russian Federation	Site Reference ID/Investigator# 28599	Stavropol
Russian Federation	Site Reference ID/Investigator# 29005	Stavropol
Russian Federation	Site Reference ID/Investigator# 29242	Stavropol
Russian Federation	Site Reference ID/Investigator# 29347	Stavropol
Russian Federation	Site Reference ID/Investigator# 29348	Stavropol
Russian Federation	Site Reference ID/Investigator# 29654	Stavropol
Russian Federation	Site Reference ID/Investigator# 28975	Tolyatti
Russian Federation	Site Reference ID/Investigator# 29463	Tolyatti
Russian Federation	Site Reference ID/Investigator# 29572	Tolyatti
Russian Federation	Site Reference ID/Investigator# 29632	Tolyatti
Russian Federation	Site Reference ID/Investigator# 29633	Tolyatti
Russian Federation	Site Reference ID/Investigator# 29094	Tyumen
Russian Federation	Site Reference ID/Investigator# 29464	Tyumen
Russian Federation	Site Reference ID/Investigator# 29466	Tyumen
Russian Federation	Site Reference ID/Investigator# 29656	Tyumen
Russian Federation	Site Reference ID/Investigator# 29657	Tyumen
Russian Federation	Site Reference ID/Investigator# 29659	Tyumen
Russian Federation	Site Reference ID/Investigator# 29661	Tyumen
Russian Federation	Site Reference ID/Investigator# 29665	Tyumen
Russian Federation	Site Reference ID/Investigator# 29672	Tyumen
Russian Federation	Site Reference ID/Investigator# 29677	Tyumen
Russian Federation	Site Reference ID/Investigator# 33324	Tyumen
Russian Federation	Site Reference ID/Investigator# 28978	Volgograd
Russian Federation	Site Reference ID/Investigator# 29250	Volgograd
Russian Federation	Site Reference ID/Investigator# 29605	Volgograd
Russian Federation	Site Reference ID/Investigator# 29606	Volgograd
Russian Federation	Site Reference ID/Investigator# 29607	Volgograd
Russian Federation	Site Reference ID/Investigator# 29251	Voronezh
Russian Federation	Site Reference ID/Investigator# 29519	Voronezh
Russian Federation	Site Reference ID/Investigator# 29521	Voronezh
Russian Federation	Site Reference ID/Investigator# 29522	Voronezh
Slovakia	Site Reference ID/Investigator# 28754	Banska Bystrica
Slovakia	Site Reference ID/Investigator# 28808	Banska Bystrica
Slovakia	Site Reference ID/Investigator# 28896	Banska Bystrica
Slovakia	Site Reference ID/Investigator# 29366	Banska Bystrica
Slovakia	Site Reference ID/Investigator# 29367	Banska Bystrica
Slovakia	Site Reference ID/Investigator# 28918	Bardejov
Slovakia	Site Reference ID/Investigator# 29129	Bardejov
Slovakia	Site Reference ID/Investigator# 29324	Bardejov
Slovakia	Site Reference ID/Investigator# 29350	Bardejov
Slovakia	Site Reference ID/Investigator# 28614	Bratislava
Slovakia	Site Reference ID/Investigator# 28693	Bratislava
Slovakia	Site Reference ID/Investigator# 28694	Bratislava
Slovakia	Site Reference ID/Investigator# 28717	Bratislava
Slovakia	Site Reference ID/Investigator# 28745	Bratislava
Slovakia	Site Reference ID/Investigator# 28749	Bratislava
Slovakia	Site Reference ID/Investigator# 28757	Bratislava
Slovakia	Site Reference ID/Investigator# 28849	Bratislava
Slovakia	Site Reference ID/Investigator# 28889	Bratislava
Slovakia	Site Reference ID/Investigator# 28932	Bratislava
Slovakia	Site Reference ID/Investigator# 29415	Bratislava
Slovakia	Site Reference ID/Investigator# 29416	Bratislava
Slovakia	Site Reference ID/Investigator# 29417	Bratislava
Slovakia	Site Reference ID/Investigator# 40734	Bratislava
Slovakia	Site Reference ID/Investigator# 28879	Cierne
Slovakia	Site Reference ID/Investigator# 29388	Detva
Slovakia	Site Reference ID/Investigator# 29389	Detva
Slovakia	Site Reference ID/Investigator# 29357	Dudince
Slovakia	Site Reference ID/Investigator# 29358	Dudince
Slovakia	Site Reference ID/Investigator# 28880	Dunajska Streda
Slovakia	Site Reference ID/Investigator# 29364	Dunajska Streda
Slovakia	Site Reference ID/Investigator# 29365	Dunajska Streda
Slovakia	Site Reference ID/Investigator# 29312	Galanta
Slovakia	Site Reference ID/Investigator# 29313	Galanta
Slovakia	Site Reference ID/Investigator# 29380	Galanta
Slovakia	Site Reference ID/Investigator# 29381	Galanta
Slovakia	Site Reference ID/Investigator# 29056	Hlohovec
Slovakia	Site Reference ID/Investigator# 33325	Hlohovec
Slovakia	Site Reference ID/Investigator# 29386	Hnusta
Slovakia	Site Reference ID/Investigator# 29387	Hnusta
Slovakia	Site Reference ID/Investigator# 28923	Humenne
Slovakia	Site Reference ID/Investigator# 29159	Humenne
Slovakia	Site Reference ID/Investigator# 28907	Kezmarok
Slovakia	Site Reference ID/Investigator# 29355	Kezmarok
Slovakia	Site Reference ID/Investigator# 29356	Kezmarok
Slovakia	Site Reference ID/Investigator# 29370	Kezmarok
Slovakia	Site Reference ID/Investigator# 29371	Kezmarok
Slovakia	Site Reference ID/Investigator# 28793	Kolarovo
Slovakia	Site Reference ID/Investigator# 29016	Komarno
Slovakia	Site Reference ID/Investigator# 28620	Kosice
Slovakia	Site Reference ID/Investigator# 28621	Kosice
Slovakia	Site Reference ID/Investigator# 28718	Kosice
Slovakia	Site Reference ID/Investigator# 28762	Kosice
Slovakia	Site Reference ID/Investigator# 28841	Kosice
Slovakia	Site Reference ID/Investigator# 28909	Kosice
Slovakia	Site Reference ID/Investigator# 29037	Kosice
Slovakia	Site Reference ID/Investigator# 29160	Kosice
Slovakia	Site Reference ID/Investigator# 29286	Kosice
Slovakia	Site Reference ID/Investigator# 29287	Kosice
Slovakia	Site Reference ID/Investigator# 29316	Kosice
Slovakia	Site Reference ID/Investigator# 29317	Kosice
Slovakia	Site Reference ID/Investigator# 28917	Kralovsky Chlmec
Slovakia	Site Reference ID/Investigator# 29292	Levice
Slovakia	Site Reference ID/Investigator# 29293	Levice
Slovakia	Site Reference ID/Investigator# 29310	Levice
Slovakia	Site Reference ID/Investigator# 29311	Levice
Slovakia	Site Reference ID/Investigator# 28671	Liptovsky Hradok
Slovakia	Site Reference ID/Investigator# 29382	Martin
Slovakia	Site Reference ID/Investigator# 29383	Martin
Slovakia	Site Reference ID/Investigator# 29130	Medzilaborce
Slovakia	Site Reference ID/Investigator# 28828	Michalovce
Slovakia	Site Reference ID/Investigator# 29284	Modra
Slovakia	Site Reference ID/Investigator# 29285	Modra
Slovakia	Site Reference ID/Investigator# 28622	Moldava nad Bodvou
Slovakia	Site Reference ID/Investigator# 28835	Nitra
Slovakia	Site Reference ID/Investigator# 29028	Nitra
Slovakia	Site Reference ID/Investigator# 29302	Nitra
Slovakia	Site Reference ID/Investigator# 29351	Nova Dubnica
Slovakia	Site Reference ID/Investigator# 29352	Nova Dubnica
Slovakia	Site Reference ID/Investigator# 29398	Nove Mesto nad Vahom
Slovakia	Site Reference ID/Investigator# 29399	Nove Mesto nad Vahom
Slovakia	Site Reference ID/Investigator# 29294	Nove Zamke
Slovakia	Site Reference ID/Investigator# 29295	Nove Zamke
Slovakia	Site Reference ID/Investigator# 29363	Nove Zamke
Slovakia	Site Reference ID/Investigator# 29304	Nove Zamky
Slovakia	Site Reference ID/Investigator# 29305	Nove Zamky
Slovakia	Site Reference ID/Investigator# 29362	Nove Zamky
Slovakia	Site Reference ID/Investigator# 28695	Novy Smokovec
Slovakia	Site Reference ID/Investigator# 28743	Partizanske
Slovakia	Site Reference ID/Investigator# 28744	Pezinok
Slovakia	Site Reference ID/Investigator# 28734	Piestany
Slovakia	Site Reference ID/Investigator# 29378	Poprad
Slovakia	Site Reference ID/Investigator# 29379	Poprad
Slovakia	Site Reference ID/Investigator# 28637	Presov
Slovakia	Site Reference ID/Investigator# 29353	Presov
Slovakia	Site Reference ID/Investigator# 29354	Presov
Slovakia	Site Reference ID/Investigator# 29397	Presov
Slovakia	Site Reference ID/Investigator# 28881	Prievidza
Slovakia	Site Reference ID/Investigator# 29314	Prievidza
Slovakia	Site Reference ID/Investigator# 29315	Prievidza
Slovakia	Site Reference ID/Investigator# 29374	Prievidza
Slovakia	Site Reference ID/Investigator# 29375	Prievidza
Slovakia	Site Reference ID/Investigator# 29320	Rimavska Sobota
Slovakia	Site Reference ID/Investigator# 29321	Rimavska Sobota
Slovakia	Site Reference ID/Investigator# 28838	Roznava
Slovakia	Site Reference ID/Investigator# 28761	Ruzomberok
Slovakia	Site Reference ID/Investigator# 29306	Ruzomberok
Slovakia	Site Reference ID/Investigator# 29307	Ruzomberok
Slovakia	Site Reference ID/Investigator# 29372	Ruzomberok
Slovakia	Site Reference ID/Investigator# 29373	Ruzomberok
Slovakia	Site Reference ID/Investigator# 29308	Sahy
Slovakia	Site Reference ID/Investigator# 29309	Sahy
Slovakia	Site Reference ID/Investigator# 28638	Sala
Slovakia	Site Reference ID/Investigator# 28832	Senec
Slovakia	Site Reference ID/Investigator# 28897	Senec
Slovakia	Site Reference ID/Investigator# 28812	Senica
Slovakia	Site Reference ID/Investigator# 28691	Sirk
Slovakia	Site Reference ID/Investigator# 28920	Snina
Slovakia	Site Reference ID/Investigator# 29083	Snina
Slovakia	Site Reference ID/Investigator# 6367	Snina
Slovakia	Site Reference ID/Investigator# 28629	Sobrance
Slovakia	Site Reference ID/Investigator# 29394	Spisska Nova Ves
Slovakia	Site Reference ID/Investigator# 29395	Spisska Nova Ves
Slovakia	Site Reference ID/Investigator# 29296	Stara Lubovna
Slovakia	Site Reference ID/Investigator# 29297	Stara Lubovna
Slovakia	Site Reference ID/Investigator# 28771	Stara Tura
Slovakia	Site Reference ID/Investigator# 29298	Svidnik
Slovakia	Site Reference ID/Investigator# 29299	Svidnik
Slovakia	Site Reference ID/Investigator# 28763	Svit 14
Slovakia	Site Reference ID/Investigator# 28903	Topolcany
Slovakia	Site Reference ID/Investigator# 29282	Topolcany
Slovakia	Site Reference ID/Investigator# 29283	Topolcany
Slovakia	Site Reference ID/Investigator# 29391	Tornala
Slovakia	Site Reference ID/Investigator# 28919	Trebisov
Slovakia	Site Reference ID/Investigator# 28764	Trencianske Teplice
Slovakia	Site Reference ID/Investigator# 28806	Trencin
Slovakia	Site Reference ID/Investigator# 29119	Trencin
Slovakia	Site Reference ID/Investigator# 29133	Trencin
Slovakia	Site Reference ID/Investigator# 28667	Trnava
Slovakia	Site Reference ID/Investigator# 28805	Trnava
Slovakia	Site Reference ID/Investigator# 28892	Trnava
Slovakia	Site Reference ID/Investigator# 28910	Trnava
Slovakia	Site Reference ID/Investigator# 28929	Trnava
Slovakia	Site Reference ID/Investigator# 29359	Trnava
Slovakia	Site Reference ID/Investigator# 29360	Trnava
Slovakia	Site Reference ID/Investigator# 29384	Trnava
Slovakia	Site Reference ID/Investigator# 29385	Trnava
Slovakia	Site Reference ID/Investigator# 29288	Turcianske Teplice
Slovakia	Site Reference ID/Investigator# 29289	Turcianske Teplice
Slovakia	Site Reference ID/Investigator# 28690	Turzovka
Slovakia	Site Reference ID/Investigator# 28716	Velke Kapusany
Slovakia	Site Reference ID/Investigator# 28921	Velke Zaluzie
Slovakia	Site Reference ID/Investigator# 28819	Velky Biel
Slovakia	Site Reference ID/Investigator# 28883	Velky Krtis
Slovakia	Site Reference ID/Investigator# 29303	Vrable
Slovakia	Site Reference ID/Investigator# 29368	Vranov nad Topl'ou
Slovakia	Site Reference ID/Investigator# 29369	Vranov nad Topl'ou
Slovakia	Site Reference ID/Investigator# 29023	Vrutky
Slovakia	Site Reference ID/Investigator# 28688	Zavar
Slovakia	Site Reference ID/Investigator# 28736	Ziar nad Hronom
Slovakia	Site Reference ID/Investigator# 28686	Zilina
Slovakia	Site Reference ID/Investigator# 28829	Zilina
Slovakia	Site Reference ID/Investigator# 29290	Zilina
Slovakia	Site Reference ID/Investigator# 29291	Zilina
Slovakia	Site Reference ID/Investigator# 29322	Zilina
Slovakia	Site Reference ID/Investigator# 29323	Zilina
Slovakia	Site Reference ID/Investigator# 29318	Zlate Moravce
Slovakia	Site Reference ID/Investigator# 29319	Zlate Moravce
Slovenia	Site Reference ID/Investigator# 30484	Adjovscina
Slovenia	Site Reference ID/Investigator# 30485	Adjovscina
Slovenia	Site Reference ID/Investigator# 6366	Adjovscina
Slovenia	Site Reference ID/Investigator# 33326	Bled
Slovenia	Site Reference ID/Investigator# 33327	Bled
Slovenia	Site Reference ID/Investigator# 28625	Celje
Slovenia	Site Reference ID/Investigator# 29033	Celje
Slovenia	Site Reference ID/Investigator# 29837	Celje
Slovenia	Site Reference ID/Investigator# 30486	Celje
Slovenia	Site Reference ID/Investigator# 30487	Celje
Slovenia	Site Reference ID/Investigator# 28587	Cerknica
Slovenia	Site Reference ID/Investigator# 33328	Cerknica
Slovenia	Site Reference ID/Investigator# 30088	Deskle
Slovenia	Site Reference ID/Investigator# 30145	Dol pri Hrastniku
Slovenia	Site Reference ID/Investigator#28729	Dolenjske toplice
Slovenia	Site Reference ID/Investigator# 28775	Domzale
Slovenia	Site Reference ID/Investigator# 30186	Fram
Slovenia	Site Reference ID/Investigator# 29918	Golnik
Slovenia	Site Reference ID/Investigator# 33331	Golnik
Slovenia	Site Reference ID/Investigator# 29040	Grosuplje
Slovenia	Site Reference ID/Investigator# 30488	Grosuplje
Slovenia	Site Reference ID/Investigator# 29955	Ilirska Bistrica
Slovenia	Site Reference ID/Investigator# 30490	Jesenice
Slovenia	Site Reference ID/Investigator# 30491	Jesenice
Slovenia	Site Reference ID/Investigator# 30492	Jesenice
Slovenia	Site Reference ID/Investigator# 28689	Koper
Slovenia	Site Reference ID/Investigator# 30164	Kostanjevica na Krki
Slovenia	Site Reference ID/Investigator# 29438	Kranj
Slovenia	Site Reference ID/Investigator# 29439	Kranj
Slovenia	Site Reference ID/Investigator# 30204	Kranj
Slovenia	Site Reference ID/Investigator# 30494	Kranj
Slovenia	Site Reference ID/Investigator# 30495	Kranj
Slovenia	Site Reference ID/Investigator# 30496	Kranj
Slovenia	Site Reference ID/Investigator# 30000	Kropa
Slovenia	Site Reference ID/Investigator# 29168	Krsko
Slovenia	Site Reference ID/Investigator# 29821	Krsko
Slovenia	Site Reference ID/Investigator# 30117	Limbus
Slovenia	Site Reference ID/Investigator# 28720	Litija
Slovenia	Site Reference ID/Investigator# 28884	Litija
Slovenia	Site Reference ID/Investigator# 28727	Ljubljana
Slovenia	Site Reference ID/Investigator# 28779	Ljubljana
Slovenia	Site Reference ID/Investigator# 29015	Ljubljana
Slovenia	Site Reference ID/Investigator# 29171	Ljubljana
Slovenia	Site Reference ID/Investigator# 29751	Ljubljana
Slovenia	Site Reference ID/Investigator# 29996	Ljubljana
Slovenia	Site Reference ID/Investigator# 30012	Ljubljana
Slovenia	Site Reference ID/Investigator# 30199	Ljubljana
Slovenia	Site Reference ID/Investigator# 30498	Ljubljana
Slovenia	Site Reference ID/Investigator# 30499	Ljubljana
Slovenia	Site Reference ID/Investigator# 30500	Ljubljana
Slovenia	Site Reference ID/Investigator# 30501	Ljubljana
Slovenia	Site Reference ID/Investigator# 30502	Ljubljana
Slovenia	Site Reference ID/Investigator# 30503	Ljubljana
Slovenia	Site Reference ID/Investigator# 28715	Ljutomer
Slovenia	Site Reference ID/Investigator# 30120	Ljutomer
Slovenia	Site Reference ID/Investigator# 30505	Logatec
Slovenia	Site Reference ID/Investigator# 28930	Maribor
Slovenia	Site Reference ID/Investigator# 29460	Maribor
Slovenia	Site Reference ID/Investigator# 29461	Maribor
Slovenia	Site Reference ID/Investigator# 29679	Maribor
Slovenia	Site Reference ID/Investigator# 30017	Maribor
Slovenia	Site Reference ID/Investigator# 30018	Maribor
Slovenia	Site Reference ID/Investigator# 30128	Maribor
Slovenia	Site Reference ID/Investigator# 30221	Maribor
Slovenia	Site Reference ID/Investigator# 30507	Maribor
Slovenia	Site Reference ID/Investigator# 30508	Maribor
Slovenia	Site Reference ID/Investigator# 28640	Markovci
Slovenia	Site Reference ID/Investigator# 2392	Mezica
Slovenia	Site Reference ID/Investigator# 28642	Miklavz na Dravskem polju
Slovenia	Site Reference ID/Investigator# 28951	Murska Sobota
Slovenia	Site Reference ID/Investigator# 30005	Murska Sobota
Slovenia	Site Reference ID/Investigator# 30081	Murska Sobota
Slovenia	Site Reference ID/Investigator# 30196	Muta
Slovenia	Site Reference ID/Investigator# 28952	Naklo
Slovenia	Site Reference ID/Investigator# 30087	Nazarje
Slovenia	Site Reference ID/Investigator# 28958	Nova Gorica
Slovenia	Site Reference ID/Investigator# 28959	Novo mesto
Slovenia	Site Reference ID/Investigator# 30142	Novo mesto
Slovenia	Site Reference ID/Investigator# 30125	Oplotnica
Slovenia	Site Reference ID/Investigator# 30509	Ormoz
Slovenia	Site Reference ID/Investigator# 30510	Ormoz
Slovenia	Site Reference ID/Investigator# 30131	Polzela
Slovenia	Site Reference ID/Investigator# 29920	Postojna
Slovenia	Site Reference ID/Investigator# 30119	Postojna
Slovenia	Site Reference ID/Investigator# 30511	Prevalje
Slovenia	Site Reference ID/Investigator# 30512	Prevalje
Slovenia	Site Reference ID/Investigator# 28810	Ptuj
Slovenia	Site Reference ID/Investigator# 28850	Ptuj
Slovenia	Site Reference ID/Investigator# 28983	Ptuj
Slovenia	Site Reference ID/Investigator# 30147	Ptuj
Slovenia	Site Reference ID/Investigator# 30123	Puconci
Slovenia	Site Reference ID/Investigator# 33329	Radece
Slovenia	Site Reference ID/Investigator# 29906	Radenci
Slovenia	Site Reference ID/Investigator# 28985	Radovljica
Slovenia	Site Reference ID/Investigator# 30124	Radovljica
Slovenia	Site Reference ID/Investigator# 30095	Ravne na Koroskem
Slovenia	Site Reference ID/Investigator# 30513	Ravne na Koroskem
Slovenia	Site Reference ID/Investigator# 30514	Ravne na Koroskem
Slovenia	Site Reference ID/Investigator# 30135	Ribnica
Slovenia	Site Reference ID/Investigator# 33330	Rogaska Slatina
Slovenia	Site Reference ID/Investigator# 28885	Ruse
Slovenia	Site Reference ID/Investigator# 30162	Senovo
Slovenia	Site Reference ID/Investigator# 28738	Sentilj v Slovenskih goricah
Slovenia	Site Reference ID/Investigator# 28609	Sentjur pri Celju
Slovenia	Site Reference ID/Investigator# 30163	Sentjur pri Celju
Slovenia	Site Reference ID/Investigator# 30015	Sevnica
Slovenia	Site Reference ID/Investigator# 30113	Sevnica
Slovenia	Site Reference ID/Investigator# 30168	Sevnica
Slovenia	Site Reference ID/Investigator# 30517	Sevnica
Slovenia	Site Reference ID/Investigator# 30518	Sevnica
Slovenia	Site Reference ID/Investigator# 30130	Sezana
Slovenia	Site Reference ID/Investigator# 28851	Skofljica
Slovenia	Site Reference ID/Investigator# 29125	Sladki vrh
Slovenia	Site Reference ID/Investigator# 28825	Slovenska Bistrica
Slovenia	Site Reference ID/Investigator# 28994	Slovenske Konjice
Slovenia	Site Reference ID/Investigator# 29917	Sostanj
Slovenia	Site Reference ID/Investigator# 28641	Straza
Slovenia	Site Reference ID/Investigator# 29090	Tolmin
Slovenia	Site Reference ID/Investigator# 30519	Trebnje
Slovenia	Site Reference ID/Investigator# 30520	Trebnje
Slovenia	Site Reference ID/Investigator# 29093	Turnisce
Slovenia	Site Reference ID/Investigator# 29098	Velenje
Slovenia	Site Reference ID/Investigator# 29045	Vojnik
Slovenia	Site Reference ID/Investigator# 30121	Vrhnika
Slovenia	Site Reference ID/Investigator# 28618	Zagorje
Slovenia	Site Reference ID/Investigator# 30144	Zagorje
Slovenia	Site Reference ID/Investigator# 28639	Zalec
Slovenia	Site Reference ID/Investigator# 30187	Zalec
Slovenia	Site Reference ID/Investigator# 29106	Zrece
Slovenia	Site Reference ID/Investigator# 30195	Zrece
Ukraine	Site Reference ID/Investigator# 10476	Dnipropetrovsk
Ukraine	Site Reference ID/Investigator# 30523	Dnipropetrovsk
Ukraine	Site Reference ID/Investigator# 30524	Dnipropetrovsk
Ukraine	Site Reference ID/Investigator# 30525	Dnipropetrovsk
Ukraine	Site Reference ID/Investigator# 30526	Dnipropetrovsk
Ukraine	Site Reference ID/Investigator# 30527	Donetsk
Ukraine	Site Reference ID/Investigator# 30528	Donetsk
Ukraine	Site Reference ID/Investigator# 30529	Donetsk
Ukraine	Site Reference ID/Investigator# 30530	Donetsk
Ukraine	Site Reference ID/Investigator# 30541	Kharkov
Ukraine	Site Reference ID/Investigator# 30542	Kharkov
Ukraine	Site Reference ID/Investigator# 30543	Kharkov
Ukraine	Site Reference ID/Investigator# 30544	Kharkov
Ukraine	Site Reference ID/Investigator# 30636	Kiev
Ukraine	Site Reference ID/Investigator# 30637	Kiev
Ukraine	Site Reference ID/Investigator# 30638	Kiev
Ukraine	Site Reference ID/Investigator# 30639	Kiev
Ukraine	Site Reference ID/Investigator# 30640	Kiev
Ukraine	Site Reference ID/Investigator# 30641	Kiev
Ukraine	Site Reference ID/Investigator# 30642	Kiev
Ukraine	Site Reference ID/Investigator# 30643	Kiev
Ukraine	Site Reference ID/Investigator# 30644	Kiev
Ukraine	Site Reference ID/Investigator# 30645	Kiev
Ukraine	Site Reference ID/Investigator# 30646	Kiev
Ukraine	Site Reference ID/Investigator# 30647	Kiev
Ukraine	Site Reference ID/Investigator# 30546	Lugansk
Ukraine	Site Reference ID/Investigator# 30547	Lugansk
Ukraine	Site Reference ID/Investigator# 30548	Lugansk
Ukraine	Site Reference ID/Investigator# 30545	Lugansk 91000
Ukraine	Site Reference ID/Investigator# 30549	Lviv
Ukraine	Site Reference ID/Investigator# 30550	Lviv
Ukraine	Site Reference ID/Investigator# 30551	Lviv
Ukraine	Site Reference ID/Investigator# 30552	Lviv
Ukraine	Site Reference ID/Investigator# 30610	Odessa
Ukraine	Site Reference ID/Investigator# 30611	Odessa
Ukraine	Site Reference ID/Investigator# 30612	Odessa
Ukraine	Site Reference ID/Investigator# 30613	Odessa
Ukraine	Site Reference ID/Investigator# 30634	Sevastopol
Ukraine	Site Reference ID/Investigator# 30635	Sevastopol
Ukraine	Site Reference ID/Investigator# 30607	Simferopol'
Ukraine	Site Reference ID/Investigator# 30608	Simferopol'
Ukraine	Site Reference ID/Investigator# 30609	Simferopol'
Ukraine	Site Reference ID/Investigator# 30648	Vinnitsa
Ukraine	Site Reference ID/Investigator# 30649	Vinnitsa
Ukraine	Site Reference ID/Investigator# 30650	Vinnitsa
Ukraine	Site Reference ID/Investigator# 30651	Vinnitsa
Ukraine	Site Reference ID/Investigator# 30596	Zaporizhzhya
Ukraine	Site Reference ID/Investigator# 30597	Zaporizhzhya
Ukraine	Site Reference ID/Investigator# 30598	Zaporizhzhya
Ukraine	Site Reference ID/Investigator# 30599	Zaporizhzhya

Sponsors (1)

Lead Sponsor	Collaborator
Abbott

Countries where clinical trial is conducted

Bulgaria,  Czech Republic,  Romania,  Russian Federation,  Slovakia,  Slovenia,  Ukraine, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reduction in Systolic Blood Pressure and Diastolic Blood Pressure From Baseline to Study End	Participants were to be followed for 6 months. Changes in systolic and diastolic blood pressure were assessed by comparing the blood pressure measurements obtained at the end of Tarka treatment (approximately 6 months) to baseline values. For this analysis of effectiveness the last available value was considered the analysis time point "end of study".	Baseline to 6 months/study end	No
Secondary	Percentage of Participants Achieving Target Blood Pressure (Less Than 140/90) at Study End and the Need for Other Antihypertensive Drugs, Clustered by Type(s) of Drugs Added to Tarka.	The percentages of participants achieving and not achieving the target blood pressure of less than 140/90 mmHg at the end of the study are presented. Percentages of participants taking Tarka only or taking Tarka plus another antihypertensive drug are summarized by type of drug: beta blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium antagonists, diuretics, and angiotensin II (AT-II) receptor antagonists. Participants taking drugs that did not fit any of the above groups (Other), unknown drugs (Unknown), or more than one additional antihypertensive agent are also summarized.	6 months	No
Secondary	Evaluation of Adverse Events (AEs) Leading to Discontinuation of Tarka and a Summary of All AEs Possibly or Probably Related to Tarka by Frequency and Severity	The number of AEs leading to Tarka discontinuation are summarized. AEs that were considered by the investigator to be possibly or probably related to Tarka are summarized by the severity of the AE (classified as mild, moderate, or severe). AEs considered possibly or probably related to Tarka that led to the discontinuation of Tarka are also presented by severity.	6 months	No