Hypertension Clinical Trial
Official title:
Effects of Strength Training and Walking Training on Physical Fitness of Patients With Intermittent Claudication
Background: Muscle atrophy and reduced leg strength are related to exercise intolerance in
patients with intermittent claudication (IC), suggesting that strength training (ST) could
improve exercise performance in these patients.
Objective: Analyze the effects of ST in walking capacity in patients with IC comparing with
walking training (WT) effects.
Intervention: Patients were randomized into ST and WT. Both groups trained twice a week, for
12 weeks, at the same rate of perceived exertion. ST consisted of 3 sets of 10 repetitions
of whole body exercises. WT consisted of 15 two-minute bouts of walking intercalated with 2
minutes of resting.
Measurements: Walking capacity, peak VO2, walking economy, ankle brachial index, ischemic
window and knee extension strength
From July 2005 to December 2006, three hundred patients with peripheral arterial disease,
who were enrolled in a tertiary center specialized in vascular disease and were able to walk
for at least 2 minutes at 2 miles per hour, were invited to a meeting at which explanations
about this study were given. 80 patients attended the meeting, 60 of them decided to take
part of the study, and 52 attended for the screening tests.
Patients were included in the study if they met the following criteria: Fontaine stage II
peripheral arterial disease, symptoms of IC for at least 6 months, ankle/brachial index
(ABI) at rest ≤ 0.90 in 1 or 2 legs, reduction of ABI after treadmill test, and exercise
tolerance limited by IC. Patients were excluded under the following conditions: presence of
chronic lung disease, inability to obtain ABI measurement due to noncompressible vessels,
exercise tolerance limited by factors other than claudication (eg, dyspnea or orthopedic
problems), poorly controlled blood pressure, presence of electrocardiogram response
suggestive of myocardial ischemia during the exercise test, and history of revascularization
in the previous year.
Procedures Patients were randomly (by drawing lots) divided into 2 groups: strength (ST, n =
17) and walking (WT, n = 17) training. They were evaluated at baseline (pre-training) and
after 12 weeks of exercise training (post-training). During evaluations were assessed
exercise tolerance and strength.
Both training programs (ST and WT) were supervised, conducted twice a week, lasted for 12
weeks, and started after a 2-week preconditioning-orientation phase. In both programs, rate
of perceived exertion during exercise was kept similar and between 11 to 13 on the15-grade
Borg scale. Furthermore, the duration of exercise sessions was prescribed as 30 min of
exercise for ST and WT groups.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
| Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
| Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
| Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
| Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
| Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
| Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
| Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
| Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
| Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
| Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
| Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
| Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
| Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
| Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |