Hypertension Clinical Trial
Official title:
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers
A couple of studies have shown that illuminating the eye with diffuse flickering light is
accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and
retinal blood flow. We have recently used this visual stimulation technique as a new and
powerful tool for the non-invasive investigation of vascular reactivity. Additionally, we
could show that this response is diminished in patients with vascular pathologies and that
the response is dependent on nitric oxide, indicating that flicker induced vasodilatation
may reflect endothelial dysfunction and may be a new approach to test endothelial function
in vivo.
One of the most widely used method for the assessment of endothelial function is flow
mediated dilatation (FMD). FMD has been shown to give a reliable estimate of vascular
function in vivo. In the present study, we set out to compare the standard method for the
evaluation of endothelial function, FMD, to flicker induced vasodilatation in the retina.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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