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Effect Baroreflex Activation Therapy on the Carotid Body

Hypertension Resistant To Conventional Therapy Clinical Trial

Official title:
Carotid Baroreflex Activation and Its Effect on the Chemoreflex Study

Clinical Trial Summary

Carotid baroreflex activation therapy (BAT) by the Rheos® system produces a sustained fall in blood pressure in patients with resistant hypertension. Since the activation electrodes are implanted at the level of the carotid sinus, it is conceivable that the nearby located carotid body chemoreceptors are stimulated as well. Physiological stimulation of carotid chemoreceptors not only raises respiration, but it also increases sympathetic activity which may in part counteract the effects of BAT. The aim of the present study is to investigate whether there is evidence for concomitant carotid chemoreflex activation during BAT. We hypothesized that there is no clinically relevant co-activation of the carotid body chemoreceptors during BAT in patients with resistant hypertension.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02210923
Study type Observational
Source Maastricht University Medical Center
Contact Teba Alnima, MD
Phone 003143 3875367
Email teba.alnima@mumc.nl
Status Recruiting
Phase N/A
Start date October 2013
View Details
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