Hyperoxia Clinical Trial
Official title:
The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric Patients and the Preventive Role of Oxygen Reserve Index"
Oxygen therapy is the most common treatment modality for patients with hypoxemia, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation. Even though there are many side effects reported related to hyperoxemia and hyperoxemia is shown to be related to worse outcome than expected; clinicians still observe hyperoxemia frequently. Oxygen reserve index (ORi™) (Masimo Corp., Irvine, USA) can guide clinicians in detection of hyperoxia. ORi is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORi that it might be helpful to reduce hyperoxia in general anesthesia. Continuous ORi monitoring can be used for detecting and preventing hyperoxia. The ability to perform FiO2 titration with ORi may be an appropriate monitoring management to prevent the harmful effects of hyperoxia.In this study, in patients who underwent major abdominal surgery; It was aimed to investigate the effectiveness of ORi-guided FiO2 titration in preventing hyperoxia.
Status | Not yet recruiting |
Enrollment | 60 |
Est. completion date | July 1, 2024 |
Est. primary completion date | June 20, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: 1. Patients aged 65 and older 2. Patients expected to have surgery lasting more than 2 hours 3. Patients with ASA (American Society of Anesthesiologists) classification 1-2-3-4 4. Patients planned to have at least 2 days of postoperative hospitalization Exclusion Criteria: 1. Patients with preoperative central nervous system disorders or dementia 2. Patients with MMSE (Mini-Mental State Examination) scores of 23 or below 3. Patients unable to communicate 4. Emergency surgeries 5. Patients who refuse to participate in the study 6. Patients using high-dose vasopressors 7. Patients with peripheral hypoperfusion 8. Hemodynamically unstable patients |
Country | Name | City | State |
---|---|---|---|
Turkey | Aykut Saritas | I?zmi?r |
Lead Sponsor | Collaborator |
---|---|
Tepecik Training and Research Hospital |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Correlation of FiO2 and ORi value | Correlation of FiO2 value and ORi value. FiO2 adjusted until ORi reaches to zero and %95Until the surgery is over |
| |
Primary | Correlation of ORi and Delirium | Correlation of ORI and SpO2 values with delirium measured by CAM and CAM-ICU | Up to 48 hours | |
Secondary | Correlation of FiO2 and delirium | Correlation of FiO2 and delirium measured by CAM and CAM-ICU | first 10 th minutes after entubation and every 10 minutes until surgery is over |
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