Hyperoxia Clinical Trial
Official title:
Impact of Intraoperative High Inspired OXygen Fraction on Pulmonary Function, Surgical Site Infection, Postoperative Nausea and Vomiting in PEDiatric Anesthesia, the OXPED Study
This study is aiming at assessing the effect of inspired oxygen fraction during general anesthesia on children's lung mechanics and volume. More specifically, the temporal change in end-expiratory lung volume (EELV) and respiratory system resistance and elastance during the perioperative period will be characterized in order to define the the effect of high inspired fraction of oxygen on lung function.
High-enriched oxygen fractions (FiO2)are common practice during general anesthesia both to
ensure normoxemia despite intrapulmonary shunts and to provide security in case of adverse
events. However, high-inspired oxygen fraction may decrease ventilation-perfusion ratios and
its benefits are still unproven in children.
The investigators aim at assessing the benefits and potential adverse effects of
high-inspired oxygen fraction in two groups of children receiving either 30% FiO2 or 80% FiO2
during maintenance of anesthesia. Nitrogen multiple breath washout technique and forced
oscillation technique will be used to measure end-expiratory lung volume (EELV) and airway
resistance (Rrs) and respiratory elastance (Xrs) respectively. These measurements will be
obtained before the general anesthesia, one hour and one day after the procedure.
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