Hyperoxia Clinical Trial
Official title:
Prospective Multicentre Observational Study on the Incidence of Hyperoxia in Non-intubated Patients in Intensive Care in Belgium Study OxSIZgen
Oxygen is the most widely prescribed therapy in the ICU (intensive care unit) and can save
lives in critical patients. While the deleterious effects of hypoxia are apparent and must be
actively avoided, hyperoxia also has adverse effects. These include systemic, coronary and
cerebral vasoconstriction; decreased coronary blood flow; pulmonary atelectasis and increased
free radicals. Despite these deleterious effects, hyperoxia is common and frequent in the ICU
(from 22% to 74%).
A recent meta-analysis published in "The Lancet" with more than 16,000 patients demonstrated
an association between liberal oxygen therapy and mortality in critical patients. Other
meta-analyses confirm its results with high quality data according to the authors.
A randomized controlled trial published in "The New England Journal of Medicine" comparing
liberal versus conservative oxygen therapy showed no difference in mechanical ventilation
days and mortality (The ICU-ROX, 2019). However, the difference in PaO2 between the two
groups was very small and the PaO2 in the liberal group did not exceed 100 mmHg. In any case,
conservative oxygen therapy is safe for critical patients.
The recommendations therefore recommend an oxygen saturation between 94-97% in critical
patients and 88-92% in patients with COPD (Chronic Obstructive Pulmonary Disease) .
However, to our knowledge, no study has described the incidence of hyperoxia in non-intubated
patients in the intensive care unit.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02917668 -
Evaluation of the Risk of Hyperoxia-induced Hypercapnia in Obese Cardiac Surgery Patients
|
N/A | |
| Not yet recruiting |
NCT02201875 -
Intrinsic Periodic Pattern of Breathing
|
N/A | |
| Completed |
NCT05770583 -
The Effectiveness of FiO2 Titration Guided by the Oxygen Reserve Index in Preventing Hyperoxia.
|
N/A | |
| Not yet recruiting |
NCT02553668 -
Proteomics for Identification of Hyperoxia-induced Changes in Protein Expression
|
N/A | |
| Completed |
NCT01978158 -
Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α
|
Phase 1/Phase 2 | |
| Completed |
NCT03268590 -
Neuroimaging During Pure Oxygen Breathing
|
Phase 4 | |
| Active, not recruiting |
NCT04133740 -
Oxygenation Targets in Cardiac Surgery Patients - a Before-and-after Study
|
Phase 4 | |
| Recruiting |
NCT04866342 -
Servo Controlled Oxygen Targeting (SCO2T) Study: Masimo vs. Nellcor
|
N/A | |
| Completed |
NCT05150418 -
Supplemental Oxygen in Hypovolemia
|
Phase 1 | |
| Terminated |
NCT03550469 -
Computer-assisted Oxygen Therapy Weaning in Critically Ill Children
|
N/A | |
| Recruiting |
NCT04413097 -
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
|
N/A | |
| Completed |
NCT03464695 -
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPD
|
N/A | |
| Recruiting |
NCT04269161 -
NICU Oxygen Control Study
|
N/A | |
| Completed |
NCT02384616 -
Hyperoxygenation in Anesthetized Children
|
N/A | |
| Unknown status |
NCT01348906 -
Intermittent Normoxia Reduces Myocardial Reperfusion Injury
|
N/A | |
| Completed |
NCT04420897 -
The Effect of Intraoperative Arterial Oxygen Pressures on Early Post-Operative Patient and Graft Survival in Living Donor Kidney Transplantation
|
||
| Completed |
NCT03930979 -
The Effect of Hyperoxia on Cardiac Output
|
||
| Not yet recruiting |
NCT06326372 -
The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric Patients
|
||
| Recruiting |
NCT05412810 -
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).
|
||
| Completed |
NCT05807815 -
The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit.
|
N/A |