Hyperoxia Clinical Trial
Official title:
The Effect of Hyperoxia on Cardiac Output in Patients Undergoing Procedural Sedation in the Emergency Department.
Rational: Preoxygenation is a standard procedure before (deep) sedation in the ED. However,
there is literature suggesting that too much oxygen can be harmful. One potential detrimental
effect is a decrease in cardiac output due to coronary vasoconstriction. So far, it is
unknown if this effect is rate dependent and if it also occurs after only a short period of
hyperoxia, as patients experience during procedural sedation pre-oxygenation.
Objective: To investigate if hyperoxia has a negative effect on Cardiac index (CI) in
patients undergoing procedural sedation in the ED.
Methods: In patients needing sedation for a painful condition, non-invasive measurements of CI, stroke volume and total peripheral resistance are performed using the Clearsight non-invasive cardiac output monitoring system.. Measurements will be taken at baseline, after 1,2 and 5 minutes of 15L O2/min, and then after another 2 and 5 minutes of flush rate oxygen and during the subsequent sedation. ;
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