Obesity Clinical Trial
Official title:
Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children: a Randomized Double Blinded Placebo Controlled Trial
The purpose of the present study was to determine whether folic acid supplementation could reduce plasma homocysteine in obese children and to determine the association between dietary folate, serum folate and homocysteine level through the randomized double blinded placebo controlled trial.
Atherosclerosis is common & remains a significant clinical problem because of leading to
myocardial infarction, stroke and cardiovascular death. Many studies founded
hyperhomocysteinemia is an independent risk factor for those cardiovascular diseases which
take responsible for about 10% of total cardiovascular disease risk. Reduction of elevated
plasma homocysteine may prevent up to 25% of cardiovascular events. One of modifiable cause
of hyperhomocysteinemia is prevention of vitamin deficiency, especially folate deficiency.
Obese Thai children are probable risk for folate deficiency due to low dietary folate intake
and low serum folate level from unbalanced diet (low vegetables intake & high fat diet) and
high prevalence of thalassemia. Moreover obese children are also at risk of atherosclerosis.
However, no data have been reported about effect of folic acid supplementation on
homocysteine level in these patients.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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