Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine

Status Completed

Clinical Trial Summary

Clinical Trial Description

The purpose of this study is to investigate whether S-adenosylmethionine (SAMe), a natural substance available as a nutritional supplement, can influence blood levels of homocysteine (Hcy). More specifically, we will determine if chronic oral SAMe administration effects homocysteine metabolism in patients with vascular disease who have mild to moderate hyperhomocysteinemia through the following specific aims:

Specific Aim 1 - To determine the effect of oral SAMe (1200 mg/day) on plasma total homocysteine levels in subjects with mild to moderate hyperhomocysteinemia.

Specific Aim 2 - To determine the effect of oral SAMe (1200 mg/day) with and without supplementation of folate, vitamin B12 and B6, on plasma homocysteine levels in patients with mild to moderate hyperhomocysteinemia.

Specific Aim 3 - To determine the effect of oral SAMe (1200 mg/day) on plasma levels pf asymmetric dimethylarginine (ADMA) in subjects with mild to moderate hyperhomocysteinemia. ;

Study Design

Related Conditions & MeSH terms

Hyperhomocysteinemia

Clinical Trial Details

NCT number	NCT00473200
Study type	Interventional
Source	Baylor Research Institute
Contact
Status	Completed
Phase	Phase 1
Start date	August 2009
Completion date	July 2013

View Details

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