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Huntington Disease clinical trials

View clinical trials related to Huntington Disease.

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NCT ID: NCT06391619 Active, not recruiting - Huntington Disease Clinical Trials

Huntington's Disease Young Adult Study 2.0

HD-YAS
Start date: April 6, 2022
Phase:
Study type: Observational

The goal of this observational study is to learn about the first signs of disease in young adult carriers of the gene for Huntington's disease. The main questions to answer are: - what are the earliest signs of the disease? - can we identify the best time to intervene with treatment to prevent or delay onset of symptoms? - can we identify the most reliable markers of disease for use in prevention trials? Participants will undergo the following assessments: - clinical examination - cognitive and neuropsychiatric testing - brain imaging - biofluid sampling Researchers will compare gene carriers with matched controls to see if any of these measures show evidence of early disease effects.

NCT ID: NCT06209515 Active, not recruiting - Parkinson Disease Clinical Trials

Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study

DEGERWD
Start date: January 1, 2022
Phase:
Study type: Observational

In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH). Based on the Finnish social security number, these individuals will be linked to the the national registers of Statistics Finland and Finnish Social and Health Data Permit Authority Findata including incomes, sociodemographic factors, education, occupation, criminal records as well as to the national registers including the bought pharmaceuticals, comorbidities and causes of death. For each study case, 10 randomly selected control cases, matched with age, sex and geographical area, will be used. The aim of the study is to examine: - 1) The prevalence of criminal and other disruptive behaviour in groups of different neurodegenerative diseases prior to and after the diagnosis - 2) Changes in employment, residency,income, and marital status prior to and after the neurodegenerative disease diagnosis - 3) Hospital diagnoses and reimbursable drugs prior to and after the diagnosis - 4) Causes of death in patients with neurodegenerative disease to study excess mortality of the patients

NCT ID: NCT05769972 Active, not recruiting - Parkinson Disease Clinical Trials

Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders

CogMusT
Start date: October 13, 2021
Phase: N/A
Study type: Interventional

Mild cognitive impairment associated with movement disorders occurs in up to one third of patients in early stages of the disease, and confers an increased risk of developing dementia. Non-pharmacological interventions to improve cognition have so far been based on computer-based cognitive stimulation and rehabilitation programs. These interventions base their mechanism of action on neuroplasticity and how improvements in cognitive function will generalize to functional improvement. Despite having shown certain indicators of efficacy in previous exploratory studies and clinical trials, cognitive rehabilitation continues to show insufficient evidence and requires further study. To date, there are no previous studies using immersive virtual reality (IVR) to improve cognition. Both IVR and cognitive stimulation are based on the premise that they allow the simulation of ecological environments for rehabilitation than conventional rehabilitation, as well as being more efficient by allowing control of extraneous variables and providing safe spaces for patients. The only PD rehabilitation studies that have been conducted using IVR aimed to improve gait and balance disturbances compared to conventional physiotherapy treatment or non-immersive virtual reality (NIVR). We hypothesize that a cognitive rehabilitation program using IVR or computer-mediated cognitive stimulation could have a greater beneficial effect on the cognitive status of patients with cognitive impairment associated with movement disorders compared to other modalities such as music therapy, delaying the worsening of cognitive functions.

NCT ID: NCT05541627 Active, not recruiting - Huntington Disease Clinical Trials

A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease

Start date: October 12, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

A Phase I/II Dose-Finding Study to Evaluate Striatal Administration of AB-1001 (previously BV-101) in Adults with Early Manifest Huntington's Disease

NCT ID: NCT05475483 Active, not recruiting - Huntington Chorea Clinical Trials

Efficacy and Safety on SOM3355 in Huntington's Disease Chorea

Start date: August 2, 2022
Phase: Phase 2
Study type: Interventional

Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington's Disease with choreic movements.

NCT ID: NCT04698551 Active, not recruiting - Huntington Disease Clinical Trials

NIPD on cffDNA for Triplet Repeat Diseases

Start date: September 1, 2020
Phase:
Study type: Observational

The purprose of this study is to develop and validate an analytical NIPD test for triplet repeat disesases by NGS analysis from maternal blood, searching for the familial mutation in families at risk of having one of the following triplet repeat diseases: Huntington's disease, Myotonic dystrophy, Fragile X syndrome.. A comparison of two 3rd generation long fragment DNA sequencing techniques will be performed. These methods are based of the phasing techniques of parental haplotypes without the proband.

NCT ID: NCT04556656 Active, not recruiting - Huntington Disease Clinical Trials

PRidopidine's Outcome On Function in Huntington Disease, PROOF- HD

Start date: October 16, 2020
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy and safety of pridopidine 45mg twice daily (BID) in patients with early stage manifest Huntington Disease (HD).

NCT ID: NCT04406636 Active, not recruiting - Huntington Disease Clinical Trials

Natural History Study in Huntington Disease Gene Expansion Carriers (HDGECs) - SHIELD HD

SHIELD HD
Start date: May 19, 2020
Phase:
Study type: Observational

SHIELD HD is an international, multisite, prospective, longitudinal cohort natural history study to assess the natural history of HD and its biomarkers that are associated with modulation of the number of cytosine-adenine-guanine (CAG) repeats in the mutant Huntingtin (HTT) gene. Approximately 60 patients will be enrolled into the study and followed for up to 24 months at clinical sites in North America and Europe. The results of this study will inform assessments for a future interventional treatment trial.

NCT ID: NCT04400331 Active, not recruiting - Chorea, Huntington Clinical Trials

Open-Label Rollover Study for Continuing Valbenazine Administration for the Treatment of Chorea Associated With Huntington Disease

Start date: September 18, 2020
Phase: Phase 3
Study type: Interventional

This is a Phase 3, open-label study to evaluate the long-term safety and tolerability of valbenazine, and to provide participants continued access to valbenazine for the treatment of chorea associated with Huntington disease.

NCT ID: NCT04270604 Active, not recruiting - Cancer Clinical Trials

Biological Sample Collection for Research and Biobanking

Start date: February 6, 2012
Phase:
Study type: Observational

The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells). NYSCF uses these samples to make stem cells and other types of cells, conduct research on the samples, perform genetic testing, and/or store these samples for future use. Through this research, scientists hope to identify future treatments or even cures.