Human Immunodeficiency Virus Clinical Trial
Official title:
Factors Associated With Late HIV Diagnosis in Grampian: an Epidemiological Study
Human immunodeficiency virus (HIV) is a major global health concern which has resulted in an
estimated 39 million deaths world-wide. Although it is now a treatable medical condition
there is still avoidable morbidity and mortality associated with HIV infection in the UK.
Late diagnosis (CD4 count of <350 cells/mm3 or AIDS-defining illness irrespective of CD4
count) is associated with increased morbidity and mortality, increased risk of transmission,
impaired response to antiretroviral therapy and increased healthcare costs. In Grampian, 49%
of patients were diagnosed late between 1984 and 2011. Therefore, the aim of the study is to
determine the factors associated with late HIV diagnosis in Grampian between 2009 and 2014
to ascertain whether diagnoses could have been made earlier.
The study constitutes a secondary data analysis. Individuals newly diagnosed with HIV
between January 2009 and December 2014 were identified from a Health Protection Scotland
(HPS) database. The majority of outcome data were extracted from the existing HPS database.
Missing data were collected via a retrospective review of patient case-notes, laboratory
reports and an electronic patient management system. Patients were classified as early or
late diagnosis and comparisons were made between the groups using statistical tests. The
study sought to provide a basis for recommendations for improvement of information and
services to facilitate earlier HIV diagnosis in Grampian.
n/a
Time Perspective: Retrospective
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