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Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial) — DEPTH  

HIV Clinical Trial

Official title:
Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

Clinical Trial Summary

The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of antibiotic-resistant bacterial infections.

Clinical Trial Description

This study is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial in approximately 250 people living with HIV who have emphysema. Eligible participants will be randomized in a 1:1 fashion to doxycycline or placebo. Participants will receive 100 mg doxycycline orally or matched placebo twice a day for 72 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05382208
Study type Interventional
Source Weill Medical College of Cornell University
Contact Robert J Kaner, MD
Phone 646-962-2333
Email rkaner@med.cornell.edu
Status Recruiting
Phase Phase 2
Start date August 22, 2022
Completion date February 2027
View Details
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