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Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection — ACS  

HIV Clinical Trial

Official title:
Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection

Clinical Trial Summary

In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at treatment interruption, evolve in individuals who start combination anti-retroviral therapy (cART) during acute seroconversion. Recently infected patients will be selected based on Fiebig staging for an in depth sampling protocol at different timepoints during a 2 year follow up period. Colonbiopsies, lymphnode resection, lumbar puncture, leucapheresis and repeated peripheral venous blood-draws will be performed. Immunological, virological and genome expression analysis will be performed on the gathered samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03449706
Study type Observational
Source University Hospital, Ghent
Contact Linos Vandekerckhove, Prof. Dr.
Phone +3293323398
Email linos.vandekerckhove@ugent.be
Status Recruiting
Phase
Start date September 1, 2017
Completion date January 1, 2028
View Details
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