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Contraceptive/HIV Affecting Risk in Adolescents — CHARA  

Hiv Clinical Trial

Official title:
Contraceptive/HIV Affecting Risk in Adolescents

Clinical Trial Summary

This study will evaluate the impact of hormonal contraceptives on HIV risk associated with changes to the innate immunity in the female genital tract in a cross-sectional study. HIV risk will be evaluated by the capacity of cervical tissue to replicate HIV when challenged ex vivo and correlated to the number of CD4 T cells, DCs, and macrophages; the capacity of cervicovaginal fluid to inhibit HIV will be correlated to soluble mucosal mediators, and the vaginal microbiota. The lower genital tract samples will be collected from 120 adolescents aged 18-19 (40 using no hormonal contraception, 40 using ENG-I, 40 using LNG-IUS). For comparison, 90 adult women aged 25-45 will be equally distributed between the same groupings.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03301480
Study type Observational
Source University of Pittsburgh
Contact
Status Terminated
Phase
Start date July 31, 2017
Completion date September 17, 2018
View Details
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