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Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk

HIV Clinical Trial

Official title:
Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk

Clinical Trial Summary

This is a prospective cohort study focusing on HIV negative women. The investigators want to learn how the contraceptive methods of depot medroxyprogesterone acetate (DMPA), etonogestrel implant (Eng-Implant), levonorgestrel intrauterine device (Lng-IUD) and the ParaGard® T 380A Intrauterine Copper Contraceptive impact the vaginal immune environment.

Clinical Trial Description

The three proposed aims will evaluate the effect of four contraceptive methods (depot medroxyprogesterone acetate (DMPA), etonogestrel implant (Eng-Implant), levonorgestrel intrauterine device (Lng-IUD) and ParaGard® T 380A Intrauterine Copper Contraceptive) on: (1) HIV target immune cells within the female genital mucosa; (2) markers of T-cell activation and trafficking within the female genital mucosa; and (3) secreted cytokines and chemokines within the female genital mucosa. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02357368
Study type Interventional
Source Emory University
Contact
Status Completed
Phase Phase 4
Start date February 2015
Completion date October 23, 2019
View Details
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