HIV Clinical Trial
Official title:
Myocardial T1-mapping and T1-derived Extracellular Volume Fraction (ECV) in HIV-infection Patients With Chronic High and Low CD4+ Counts and in a Healthy Control Group
HIV-infection is associated with an increased risk for cardiovascular disease. Especially
patients with low CD4+ counts have a higher incidence of structural heart disease.
Myocardial T1 relaxation time, as well as T1-derived extracellular volume fraction are
relatively new methods for non-invasive myocardial tissue characterization, including
diffuse myocardial fibrosis.
In our study HIV-patients with high and low CD4+ counts are examined on a 3T MRI scanner
(Ingenia 3T, Philips Medical, Best, Netherlands). Scanning protocol includes common SSFP
sequences, STIR imaging and LGE [Late gadolinium enhancement]. All HIV patients are treated
in the HIV outpatient clinic of the hospital's Internal Medicine department and have an
unremarkable history of cardiac disease. Patients are recruited from all over Germany. In
order to obtain reference values, a subgroup of healthy, age-matched controls is included in
this study.
Aim of this study is to show differences in T1- and ECV-values in the investigated
subgroups. In addition, we also want to create cut-off values for healthy and affected
myocardium in asymptomatic HIV-infected patients. This study could show whether myocardial
T1 mapping is a potential screening parameter for beginning heart disease as part of an
HIV-infection, and whether an application in routine diagnostic is reasonable.
n/a
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