HIV Clinical Trial
Official title:
Metabolic Fingerprintings and Metabolic Dynamics After HIV Infection:Impact of Metabolic Changes and Anti-Retroviral Therapy, Life Style and Clinical Conditions
The purpose of this plot study is to find out the relationship between metabolic changes and anti-retroviral therapy (ART), life style and clinical conditions of HIV-infected patients using nuclear magnetic resonance (NMR) based systems biology approach and metabolomics methodology.
Since the clinical application of anti-retroviral therapy (ART) in 1997, the life expectancy
of HIV infected patients has been prolonged greatly. However,side effects of ART including
metabolic abnormalities have become the main factors influencing patients' quality of life.
Among which the abnormal lipid metabolism plays an important role. Meanwhile, metabolic
conditions differ from patients applying to different combinations of ART drugs,life style
and clinical conditions.
Metabolomics can measure the dynamic metabolic responses of the body to stimuli or
modifications. Using nuclear magnetic resonance (NMR) as tools can systematically analyse
the process of lipid metabolism. Metabolomics fingerprinting can be defined as the complete
complement of small molecule (< 1500 Da) metabolites found in a specific cell, body fluid,
organ or organism.
Therefore, the study of the impact of metabolic changes and anti-retroviral therapy (ART),
life style and clinical conditions is of importance in enhancing the adherence and improving
the clinical outcomes of HIV infected patients.
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