HIV Clinical Trial
Official title:
Arginine Rich Food Supplementation as an Adjuvant Treatment Against Tuberculosis
The purpose of this study was to investigate if adjuvant treatment with arginine (the substrate for nitric oxide production) rich food supplements could improve clinical outcome in patients with smear positive tuberculosis by affecting nitric oxide production.
Tuberculosis (TB) is disease of increased global public health importance. Because of
emerging multi drug resistance and the long treatment duration there is a need to optimize
the current chemotherapy. Host immunity is important in determining the susceptibility and
outcome of disease as could be exemplified by co infection with HIV which dramatically
increases the risk to develop TB.
Previous results from our group and others show that nitric oxide produced by activated
macrophages from arginine might be important to control the disease. However, the relative
importance of nitric oxide in human TB has been debated. In a previous study in Gondar,
Ethiopia, we observed an effect of adjuvant treatment with arginine capsules on sputum smear
conversion and reduction of cough. In this study we wanted to test the hypothesis based on
previous observations that an arginine rich food supplementation might enhance clinical
improvement in patients with smear positive tuberculosis and if this effect could be due to
increased nitric oxide production.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Supportive Care
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