HIV Clinical Trial
Official title:
Disability and HIV: an Appraisal of the Vulnerability of People With Disabilities to HIV Infection in Two Main Cities of Sub-Saharan Africa
According to the recent World Report on Disability, around 15% of the world population lives
with a disability and 80% of people with disabilities (PWD) live in developing countries.
More and more evidence show that PWD are more likely to be poor, vulnerable to physical and
sexual violence, and to have less access to education. Therefore, PWD are likely to have an
increased risk for HIV infection, potentially being a key population in regard to this
epidemic.
The vulnerability of PWD was recognized in 2007 by the United Nations Convention on the
Rights of Persons with Disabilities. However, data on the extent how PWD are affected by HIV
is still very limited. As a result, PWD are usually overlooked by National AIDS Control
Programmes and few projects specifically targeting them have been developed.
Recognizing the need for appropriate and reliable data to help protect the rights of PWD and
achieve a better inclusion of disability in National AIDS Control Programmes, the Institute
of Research for Development (IRD), the Institut de Formation et Recherche Demographique
(IFORD) and Handicap International (HI) propose this study that aims to provide quantitative
and qualitative data on the vulnerability of PWD to HIV infection in Cameroon and Burkina
Faso, in order to define if this vulnerable population is also a Key Population in relation
to the HIV epidemic. This study adopts a multidisciplinary approach (quantitative and
qualitative methods). Quantitative data are collected only in Cameroon.
Only the quantitative study is described here.
OBJECTIVES:
The general objective of this study is to provide information on the vulnerability of PWD to
HIV infection.
The objectives of the quantitative component of this study are:
Estimation of the HIV burden among PWD:
- To estimate the prevalence of HIV in PWD comprehensively and for each of the following
disabilities 1) hearing 2) visual 3) mobility 4) cognitive (intellectual)
- To compare the HIV prevalence between PWD and non-disabled matched controls
- To assess the association between PWD's social network characteristics and the risk for
HIV
Assessment of the knowledge, behaviour and practice toward HIV infection and sexual and
reproductive health (including contraception) overall and for each of the impairment groups
mentioned above:
- To describe and analyze the knowledge, attitude and behaviours related to HIV infection
- To compare the knowledge, attitude and behaviours between PWD and non-disabled matched
controls
- To describe sexual and reproductive activities of PWD
- To describe and analyze the access and actual use of family planning methods in PWD
Access to HIV prevention and health careglobally and for each of the impairment groups
mentioned above:
- To describe and analyze the determinants of and barriers to access to prevention and
testing services
- To describe and analyze the determinants of and barriers to access to care
- To compare the access to services between PWD and non-disabled matched controls
Specific objectives related to disability:
- To describe the population of PWD in Yaoundé
- To describe and analyze the characteristics of the social networks of PWD
METHODOLOGY
Study design:
This is a cross sectionnal study assessing HIV prevalence, HIV risk factors and sexual &
reproductive health of PWD compared to a control group of Non-Disabled People. PWD are
sampled from the general population using a two-step sampling method. Eligible subjects are
proposed an HIV test and to respond to a questionnaire on their Knowledge, Attitudes and
Practices (KAP) in relation to HIV and SRH, on their social network and on their access to
prevention and care services. The life-grid interview method is used to collect data on
subject's history of social participation, employment, resources, sexual partnership and
reproductive life. Controls are selected from the PWD's neighborhood.
Sample size:
850 disabled subjects and 850 non-disabled controls
Study location: Yaounde, Cameroon
Estimated planning or Study timetable :
Study start date: April 2014 (exploratory work) Total trial/study duration: 24 months
;
Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06162897 -
Case Management Dyad
|
N/A | |
Completed |
NCT03999411 -
Smartphone Intervention for Smoking Cessation and Improving Adherence to Treatment Among HIV Patients
|
Phase 4 | |
Completed |
NCT02528773 -
Efficacy of ART to Interrupt HIV Transmission Networks
|
||
Active, not recruiting |
NCT05454839 -
Preferences for Services in a Patient's First Six Months on Antiretroviral Therapy for HIV in South Africa
|
||
Recruiting |
NCT05322629 -
Stepped Care to Optimize PrEP Effectiveness in Pregnant and Postpartum Women
|
N/A | |
Completed |
NCT02579135 -
Reducing HIV Risk Among Adolescents: Evaluating Project HEART
|
N/A | |
Active, not recruiting |
NCT01790373 -
Evaluating a Youth-Focused Economic Empowerment Approach to HIV Treatment Adherence
|
N/A | |
Not yet recruiting |
NCT06044792 -
The Influence of Primary HIV-1 Drug Resistance Mutations on Immune Reconstruction in PLWH
|
||
Completed |
NCT04039217 -
Antiretroviral Therapy (ART) Persistence in Different Body Compartments in HIV Negative MSM
|
Phase 4 | |
Active, not recruiting |
NCT04519970 -
Clinical Opportunities and Management to Exploit Biktarvy as Asynchronous Connection Key (COMEBACK)
|
N/A | |
Completed |
NCT04124536 -
Combination Partner HIV Testing Strategies for HIV-positive and HIV-negative Pregnant Women
|
N/A | |
Recruiting |
NCT05599581 -
Tu'Washindi RCT: Adolescent Girls in Kenya Taking Control of Their Health
|
N/A | |
Active, not recruiting |
NCT04588883 -
Strengthening Families Living With HIV in Kenya
|
N/A | |
Completed |
NCT02758093 -
Speed of Processing Training in Adults With HIV
|
N/A | |
Completed |
NCT02500446 -
Dolutegravir Impact on Residual Replication
|
Phase 4 | |
Completed |
NCT03805451 -
Life Steps for PrEP for Youth
|
N/A | |
Active, not recruiting |
NCT03902431 -
Translating the ABCS Into HIV Care
|
N/A | |
Completed |
NCT00729391 -
Women-Focused HIV Prevention in the Western Cape
|
Phase 2/Phase 3 | |
Recruiting |
NCT05736588 -
Elimisha HPV (Human Papillomavirus)
|
N/A | |
Recruiting |
NCT03589040 -
Darunavir and Rilpivirine Interactions With Etonogestrel Contraceptive Implant
|
Phase 2 |