HIV Clinical Trial
Official title:
Post-prandial Lipid Effects of Raltegravir (RAL) vs Ritonavir-boosted Darunavir (DRV-r) in Anti-retroviral Therapy (ART)-Naive Adults or Adults Recommencing ART.
This is a research study into the effects of three drugs used to treat HIV infection. Some
drugs used to treat HIV have been associated with changes in blood fats such as cholesterol
that could be harmful over the long-term, because these blood fat changes have been
associated with a small, increased risk of heart disease and stroke in some studies of
adults with HIV. Now that HIV can be controlled for long periods in most patients, and
because heart disease is one of the biggest causes of illness and death in the general
population, it is important to develop new HIV treatments that control HIV effectively but
do not cause abnormal blood fats.
Hypothesis: That Raltegravir will result in less post-prandial lipid disturbances than
ritonavir-boosted darunavir.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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