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HIV Seronegativity clinical trials

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NCT ID: NCT03995862 Completed - Clinical trials for Pre-Exposure Prophylaxis

Evaluation of Pre-Exposure Prophylaxis Against HIV in Alpine Region

PrEP2A
Start date: May 29, 2019
Phase:
Study type: Observational

Despite the implementation of a national strategy to prevent the transmission of the human immunodeficiency virus (HIV) combining prevention campaigns, condom use, early detection of HIV infections and recommendations for treatment as soon as possible, the number of new HIV-infected patients per year in France does not decrease. New HIV prevention strategies are therefore clearly needed. Since 2009, several studies have shown that tenofovir disoproxil fumarate and emtricitabine (TDF/FTC), an antiretroviral therapy combining two nucleoside reverse transcriptase inhibitors used for the treatment of patients seropositive for HIV, has preventive activity on HIV transmission. These results enabled the TDF/FTC to obtain in France an extension of the marketing authorization in March 2017 for preexposure prophylaxis (PrEP) of HIV transmission among patients at high risk of contamination. Since the approval, many studies around the world investigate the use of PrEP in routine practice, highlighting its effectiveness in real life. These studies describe the population of patients who benefit from PrEP in order to adapt their multidisciplinary care but also track the transmission of other sexually transmitted infections to prevent their emergence, given the observed decline in condom use. However, these studies are limited to big cities while PrEP is accessible in all territories. The Rhône-Alpes region is one of the three French regions that has been the most involved in the implementation of PrEP, one year after the FTC/TDF approval in France. Given the geographical position of the investigators, both in province and close to Switzerland, where the FTC/TDF is not authorized for PrEP, and the non-university nature of five of the six involved hospitals, the investigators would like to determine the profile of patients consulting in this region to benefit from PrEP. This analysis will also determine if the population at risk of the "Alpine Arc" region is similar to that observed in the other cohorts in order to adapt patient care.

NCT ID: NCT03191474 Completed - HIV Seronegativity Clinical Trials

Linkage of Transgender Individuals to PrEP

Start date: July 28, 2017
Phase: N/A
Study type: Interventional

CCTG 602 is a multisite demonstration project to evaluate the effectiveness of facilitated linkage to PrEP using a community-based transgender PrEP outreach worker (T-POWr) versus standard of care (SOC).

NCT ID: NCT03086200 Completed - HIV Seronegativity Clinical Trials

Randomized Controlled Trial of iTAB Plus Motivational Interviewing for PrEP Adherence in Transgender Individuals

Start date: June 23, 2017
Phase: N/A
Study type: Interventional

CCTG 603 is an open-label, two-arm, randomized (1:1) clinical demonstration project to determine if brief Motivational Interviewing (MI-B) added to a text-message based adherence intervention (iTAB) improves adherence to PrEP among transgender persons.

NCT ID: NCT02125773 Completed - HIV Seronegativity Clinical Trials

Pre-exposure Prophylaxis Accessibility Research and Evaluation 2

PrEPARE2
Start date: February 19, 2014
Phase: N/A
Study type: Interventional

This study is a controlled, un-blinded, two-arm, randomized (1:1) clinical trial to determine if providing high-risk subjects with a calculated risk score changes the likelihood of pre-exposure prophylaxis (PrEP) uptake.

NCT ID: NCT01761643 Completed - HIV Seronegativity Clinical Trials

CCTG 595: Text Messaging Intervention to Improve Adherence to PrEP in High-risk MSM

Start date: December 19, 2012
Phase: Phase 4
Study type: Interventional

CCTG 595 is a controlled, open-label, two-arm, randomized (1:1) clinical demonstration project to determine if the use of a text-message based adherence intervention (iTAB) improves retention and adherence to PrEP compared to standard of care (SoC) PrEP delivery.

NCT ID: NCT01418235 Completed - HIV Seronegativity Clinical Trials

Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults

Start date: December 19, 2011
Phase: Phase 1
Study type: Interventional

Sub-Saharan Africa is the region most affected by the global Human Immunodeficiency Virus (HIV) epidemic. A vaccine is the most promising preventive approach against new HIV infections. The purpose of this study is to evaluate the safety and immunogenicity of 4 experimental preventive HIV vaccine regimens in HIV-uninfected adults in South Africa.

NCT ID: NCT00789789 Terminated - HIV Infection Clinical Trials

Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials

Start date: December 2008
Phase: N/A
Study type: Observational

This cohort study should provide an exhaustive overview on long-term safety of various preventive HIV-vaccines administered in phase I and II clinical trials to healthy volunteers of the ANRS network.

NCT ID: NCT00121121 Completed - HIV Infections Clinical Trials

Safety of Intradermal Versus Intramuscular Administration of HIV Lipopeptides in HIV Uninfected Adult Volunteers

Start date: July 2004
Phase: Phase 1
Study type: Interventional

Intramuscular (IM) administration of HIV lipopeptide vaccines have been shown to be able to induce HIV-1-specific T cell-mediated immune responses. The objective of this trial was to evaluate the safety and immunogenicity of LIPO-4 vaccine (HIV lipopeptides including 4 peptides from Gag, Pol, RT and Nef HIV-1 proteins, each peptide linked to TT) intradermally (ID) compared to IM administration.

NCT ID: NCT00078182 Withdrawn - HIV Infections Clinical Trials

Daily Tenofovir DF to Prevent HIV Infection Among Sex Workers in Cambodia

Start date: n/a
Phase: Phase 2/Phase 3
Study type: Interventional

Tenofovir disoproxil fumarate (also known as tenofovir DF or Viread) is used with other anti-HIV drugs to treat HIV infection. Taking tenofovir DF every day may also prevent HIV infection. This study will determine if taking a tenofovir DF tablet every day is safe and effective in preventing HIV infection. Participants in the study will be sex workers in Phnom Penh, Cambodia.

NCT ID: NCT00076817 Completed - HIV Infections Clinical Trials

Safety and Effectiveness of Administering an HIV Vaccine in the Groin Versus the Arm

Start date: June 2006
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the safety of and immune system response to the ALVAC-HIV (vCP205) vaccine when it is injected either into the groin area or into the arm. The goal is to determine if injecting the vaccine into the groin area produces a better immune response in the lining of the rectum.