HIV Infections Clinical Trial
Official title:
Study Of The Efficacy And Security Of Ibandronate For Osteoporosis Treatment In A HIV-Infected Patients Cohort
This project wills to determine the incidence of osteoporosis in our population of HIV-infected patients and to assess the efficacy and security of ibandronate, whose efficacy in post-menopausal women has already been proved.
The lower bone mineral density that has been described in patients with HIV-infection has not
meant an increase of long term complications. Nevertheless, it could involve an increase if
the associated co-mordibity in the future, taking in care that in general population
osteoporosis increases 4 times the pathologic fracture risk. That's why it is necessary to
know the real prevalence of osteoporosis in this population of patients so the real
dimensions of the problems can be defined.
This project wills to determine the incidence of osteoporosis in our population of
HIV-infected patients and to assess the efficacy and security of ibandronate, whose efficacy
in post-menopausal women has been already proved. If the quarterly use of endovenous
ibandronate obtains equivalent results to those obtained with oral and weekly alendronate in
other studies with the same population, its use would be justified because of its posology
benefits. The monthly or quarterly administration can improve compliance in patients who are
recieving a big quantity of drugs, as HIV infected patients do and who probably have to be
treated for life. Moreover, its elimination is renal so there is absence of interactions with
antiretroviral drugs what mades of ibandronate a very promising alternative. Finally, there's
no risk of digestive intolerance because of its parenteral administration and it has a better
posology than oral bifosfonates.
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