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NCT00005309 Clinical Trial

Prospective Study of HIV Infection in Hemophiliacs

HIV Infections Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00005309
Other study ID # 3012
Secondary ID R01HL043512
Status Completed
Phase
First received
Last updated
Start date July 1990
Est. completion date March 1995

Study information
Verified date February 2016
Source Bloodworks
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.

Description:

BACKGROUND:

In the late 1980s, hemophiliacs were transfused with a variety of blood products, including large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-), resulting in a comparison group for the study of this virus as a potential cofactor. In contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary data prior to 1990 suggested that this chronic disease predisposes to more rapid progression of HIV infection.

DESIGN NARRATIVE:

Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB hepatitis infection were ascertained. Host-virus interaction was assessed through the use of plasma cultures, specific antibody titers, and markers of immune changes detected by flow cytometry and immune function assays. The immunology of asymptomatic stable infection was investigated. The safety of volunteer donor blood products was determined in seronegative patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to spouses of seropositive patients was monitored.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date March 1995
Est. primary completion date March 1995
Accepts healthy volunteers No
Gender Male
Age group N/A to 100 Years
Eligibility No eligibility criteria

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Bloodworks National Heart, Lung, and Blood Institute (NHLBI)
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