HIV Infections Clinical Trial
To examine mechanisms of individual differences in the progression of HIV infection in hemophiliacs.
BACKGROUND:
In the late 1980s, hemophiliacs were transfused with a variety of blood products, including
large amounts of cryoprecipitate. In comparison to other cohorts, hemophiliacs are CMV(-),
resulting in a comparison group for the study of this virus as a potential cofactor. In
contrast, non A, non-B hepatitis is common in comparison to other cohorts, and preliminary
data prior to 1990 suggested that this chronic disease predisposes to more rapid progression
of HIV infection.
DESIGN NARRATIVE:
Disease-free survival rates were determined in HIV-infected hemophiliacs. The effects of
co-factors such as intensive transfusion, concomitant cytomegalovirus or chronic NANB
hepatitis infection were ascertained. Host-virus interaction was assessed through the use of
plasma cultures, specific antibody titers, and markers of immune changes detected by flow
cytometry and immune function assays. The immunology of asymptomatic stable infection was
investigated. The safety of volunteer donor blood products was determined in seronegative
patients exposed to over 50,000 donors yearly and the risk of sexual transmission of HIV to
spouses of seropositive patients was monitored.
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