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Clinical Trial Summary

This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and/or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess safety, tolerability, pharmacokinetics, immunogenicity, and anti-tumor activity of XmAb22841 monotherapy and in combination with pembrolizumab in subjects with select advanced solid tumors.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Advanced or Metastatic Solid Tumors
  • Anus Neoplasms
  • Carcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Ovarian Epithelial
  • Carcinoma, Squamous Cell
  • Cervical Carcinoma
  • Cholangiocarcinoma
  • Colorectal Carcinoma
  • Colorectal Neoplasms
  • Endometrial Carcinoma
  • Endometrial Neoplasms
  • Epithelial Ovarian Cancer
  • Fallopian Tube Cancer
  • Fallopian Tube Neoplasms
  • Gastric or Gastroesophageal Junction Adenocarcinoma
  • Hepatocellular Carcinoma
  • Intrahepatic Cholangiocarcinoma
  • Lung Neoplasms
  • Melanoma
  • Nasopharyngeal Carcinoma
  • Non-small Cell Lung Carcinoma
  • Ovarian Neoplasms
  • Pancreatic Carcinoma
  • Pancreatic Neoplasms
  • Primary Peritoneal Carcinoma
  • Prostate Carcinoma
  • Renal Cell Carcinoma
  • Small Cell Lung Carcinoma
  • Squamous Cell Anal Cancer
  • Squamous Cell Carcinoma of Head and Neck
  • Squamous Cell Carcinoma of the Head and Neck
  • Squamous Cell Penile Carcinoma
  • Squamous Cell Vulvar Carcinoma
  • Triple Negative Breast Cancer
  • Triple Negative Breast Neoplasms
  • Urothelial Carcinoma
  • Vulvar Neoplasms

NCT number NCT03849469
Study type Interventional
Source Xencor, Inc.
Contact
Status Completed
Phase Phase 1
Start date May 29, 2019
Completion date February 16, 2023

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