Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma

Hepatocellular Carcinoma Clinical Trial

— PERCAHEC  

Official title:

Prediction Value of Perfusion and Dual Energy Computer Tomography for Microvascular Invasion in Hepatocellular Carcinoma

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03754192
• Other study ID #: APHP180011
• Status: Recruiting
• Phase: N/A
• Start date: January 30, 2019
• Est. completion date: December 30, 2020

Study information

• Verified date: August 2020
• Source: Assistance Publique - Hôpitaux de Paris
• Contact: LEWIN MAITE, MD, Phd
• Phone: 00 (33) 6 11 15 06 17
• Email: maite.lewin[@]aphp.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular carcinoma by comparing the quantitative parameters computer tomography obtained with the pathological data of the surgical specimens.

Description:

Dual-energy computer tomography and perfusion computer tomography (General Electric revolution Hight definition Gemstone™ Spectral Imaging) will be performed in all patients. Iodine concentration and quantitative perfusion parameters of the Hepatocellular carcinoma and surrounding liver parenchyma data will be compared with the pathological results.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: December 30, 2020
• Est. primary completion date: December 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• A diagnosis of Hepatocellular carcinoma made according to the guidelines of the American Association for the study of the Liver

• Affiliation to a national health insurance

• An indication for hepatic resection during the decision-making stage

• A request for a pre-operative Computer Tomography in our radiology unit

• An affiliation to a social security

• Informed consent given by the patient

Exclusion Criteria:

• Previous treatments of Hepatocellular carcinoma (medicated or surgical)

• Patient under tutorship or curatorship

• Pregnant or lactating woman

Related Conditions & MeSH terms

• Carcinoma
• Carcinoma, Hepatocellular
• Hepatocellular Carcinoma

Intervention

Radiation:
• perfusion Computed Tomography
Will be carried before liver surgery

Locations

Country	Name	City	State
France	CHU Paul Brousse	Villejuif

Sponsors (1)

Lead Sponsor	Collaborator
Assistance Publique - Hôpitaux de Paris

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pefusion parameters	correlation between pre-operative imaging data and histological data of Hepatocellular carcinoma	5 minutes
Secondary	Pathological examination	Compare data obtained in perfusion computer tomography to the imaging data and to the Histological differentiation grades	1 month